FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982133780> ?p ?o ?g. }

• W1982133780 endingPage "43" @default.
• W1982133780 startingPage "37" @default.
• W1982133780 abstract "Mechanical hyperalgesia induced in rat paws by carrageenan (250microg) was modified by pre-treatment with three selective inhibitors of cyclo-oxygenase-2 (COX-2); celecoxib, rofecoxib and SC236. These inhibitors raised the nociceptive threshold above the normal, non-inflamed, level, inducing a state of hypoalgesia. Such hypoalgesia was observed in different strains of rat (Holtzman, Wistar and Sprague-Dawley) and after different modes of administration of the COX-2 inhibitor (locally, in the paw, or systemically). A selective inhibitor of COX-1 (SC 560; 1-10mg kg(-1)) decreased hyperalgesia but did not induce hypoalgesia. Pre-treatment with naltrexone (3mg kg(-1)), an opioid receptor antagonist, did not affect carrageenan-induced hyperalgesia but abolished the hypoalgesic effects of COX-2 inhibitors, without diminishing the anti-hyperalgesic effect of indomethacin. In rats made tolerant to the anti-nociceptive effects of morphine, all anti-nociceptive effects of SC236 were abolished but the anti-hyperalgesic effects of indomethacin or SC 560 were unaffected. We conclude that, in our model of inflammatory hyperalgesia, the anti-nociceptive effect of selective COX-2 inhibitors involved the participation of endogenous opioids." @default.
• W1982133780 created "2016-06-24" @default.
• W1982133780 creator A5013683754 @default.
• W1982133780 creator A5014108092 @default.
• W1982133780 creator A5043757576 @default.
• W1982133780 creator A5058957898 @default.
• W1982133780 creator A5083078140 @default.
• W1982133780 creator A5083944286 @default.
• W1982133780 creator A5089213858 @default.
• W1982133780 date "2006-07-01" @default.
• W1982133780 modified "2023-09-27" @default.
• W1982133780 title "Endogenous opioids mediate the hypoalgesia induced by selective inhibitors of cyclo-oxygenase 2 in rat paws treated with carrageenan" @default.
• W1982133780 cites W1963627122 @default.
• W1982133780 cites W1974991118 @default.
• W1982133780 cites W1995099756 @default.
• W1982133780 cites W2000468755 @default.
• W1982133780 cites W2008574207 @default.
• W1982133780 cites W2023555221 @default.
• W1982133780 cites W2024608254 @default.
• W1982133780 cites W2033498682 @default.
• W1982133780 cites W2039612972 @default.
• W1982133780 cites W2040393757 @default.
• W1982133780 cites W2057793539 @default.
• W1982133780 cites W2065278888 @default.
• W1982133780 cites W2087454739 @default.
• W1982133780 cites W2092815587 @default.
• W1982133780 cites W2102368544 @default.
• W1982133780 cites W2114571150 @default.
• W1982133780 cites W2124353813 @default.
• W1982133780 cites W2134927810 @default.
• W1982133780 cites W2150804818 @default.
• W1982133780 cites W2160878378 @default.
• W1982133780 doi "https://doi.org/10.1016/j.neuropharm.2006.02.012" @default.
• W1982133780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16620880" @default.
• W1982133780 hasPublicationYear "2006" @default.
• W1982133780 type Work @default.
• W1982133780 sameAs 1982133780 @default.
• W1982133780 citedByCount "27" @default.
• W1982133780 countsByYear W19821337802012 @default.
• W1982133780 countsByYear W19821337802013 @default.
• W1982133780 countsByYear W19821337802015 @default.
• W1982133780 countsByYear W19821337802016 @default.
• W1982133780 countsByYear W19821337802017 @default.
• W1982133780 countsByYear W19821337802018 @default.
• W1982133780 countsByYear W19821337802019 @default.
• W1982133780 crossrefType "journal-article" @default.
• W1982133780 hasAuthorship W1982133780A5013683754 @default.
• W1982133780 hasAuthorship W1982133780A5014108092 @default.
• W1982133780 hasAuthorship W1982133780A5043757576 @default.
• W1982133780 hasAuthorship W1982133780A5058957898 @default.
• W1982133780 hasAuthorship W1982133780A5083078140 @default.
• W1982133780 hasAuthorship W1982133780A5083944286 @default.
• W1982133780 hasAuthorship W1982133780A5089213858 @default.
• W1982133780 hasConcept C15490471 @default.
• W1982133780 hasConcept C16613235 @default.
• W1982133780 hasConcept C170493617 @default.
• W1982133780 hasConcept C181199279 @default.
• W1982133780 hasConcept C185592680 @default.
• W1982133780 hasConcept C2775962371 @default.
• W1982133780 hasConcept C2776467144 @default.
• W1982133780 hasConcept C2776885963 @default.
• W1982133780 hasConcept C2777389121 @default.
• W1982133780 hasConcept C2777972943 @default.
• W1982133780 hasConcept C2778582115 @default.
• W1982133780 hasConcept C2778750930 @default.
• W1982133780 hasConcept C2779245659 @default.
• W1982133780 hasConcept C2779689624 @default.
• W1982133780 hasConcept C2781063702 @default.
• W1982133780 hasConcept C2781199918 @default.
• W1982133780 hasConcept C2781227287 @default.
• W1982133780 hasConcept C3017995582 @default.
• W1982133780 hasConcept C55493867 @default.
• W1982133780 hasConcept C71924100 @default.
• W1982133780 hasConcept C98274493 @default.
• W1982133780 hasConceptScore W1982133780C15490471 @default.
• W1982133780 hasConceptScore W1982133780C16613235 @default.
• W1982133780 hasConceptScore W1982133780C170493617 @default.
• W1982133780 hasConceptScore W1982133780C181199279 @default.
• W1982133780 hasConceptScore W1982133780C185592680 @default.
• W1982133780 hasConceptScore W1982133780C2775962371 @default.
• W1982133780 hasConceptScore W1982133780C2776467144 @default.
• W1982133780 hasConceptScore W1982133780C2776885963 @default.
• W1982133780 hasConceptScore W1982133780C2777389121 @default.
• W1982133780 hasConceptScore W1982133780C2777972943 @default.
• W1982133780 hasConceptScore W1982133780C2778582115 @default.
• W1982133780 hasConceptScore W1982133780C2778750930 @default.
• W1982133780 hasConceptScore W1982133780C2779245659 @default.
• W1982133780 hasConceptScore W1982133780C2779689624 @default.
• W1982133780 hasConceptScore W1982133780C2781063702 @default.
• W1982133780 hasConceptScore W1982133780C2781199918 @default.
• W1982133780 hasConceptScore W1982133780C2781227287 @default.
• W1982133780 hasConceptScore W1982133780C3017995582 @default.
• W1982133780 hasConceptScore W1982133780C55493867 @default.
• W1982133780 hasConceptScore W1982133780C71924100 @default.
• W1982133780 hasConceptScore W1982133780C98274493 @default.
• W1982133780 hasIssue "1" @default.
• W1982133780 hasLocation W19821337801 @default.
• W1982133780 hasLocation W19821337802 @default.

• next