Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982135000> ?p ?o ?g. }
- W1982135000 abstract "Many of the clinical trials in Alzheimer’s disease (AD) target the formation, accumulation or clearance of amyloid β (Aβ), which is considered to be a pathological hallmark of the disease. These trials have not yet proven efficacy in treatment or prevention of the disease. The failure of these trials may be attributed to a misconception of the role of Aβ and the second pathological hallmark of the disease, neurofibrillary tangles, in the most prevalent form of the disease, sporadic AD, compared with the rare early onset, familial AD. In this review, we discuss factors that may affect the results of clinical trials. In addition, the role of several risk factors for AD and their possible interactions with Aβ will be reviewed, suggesting a conceptualization of sporadic AD as a heterogenous clinical entity. The implications of such an approach on clinical trials for the treatment and prevention of AD will be discussed." @default.
- W1982135000 created "2016-06-24" @default.
- W1982135000 creator A5007494860 @default.
- W1982135000 creator A5048997783 @default.
- W1982135000 date "2011-11-01" @default.
- W1982135000 modified "2023-09-26" @default.
- W1982135000 title "Current conceptions of the etiology and risk factors for Alzheimer’s disease and their possible implications on the design of dementia clinical trials" @default.
- W1982135000 cites W1472735294 @default.
- W1982135000 cites W1519193588 @default.
- W1982135000 cites W152311838 @default.
- W1982135000 cites W1546258268 @default.
- W1982135000 cites W1548995643 @default.
- W1982135000 cites W1562031459 @default.
- W1982135000 cites W1566564316 @default.
- W1982135000 cites W1597130939 @default.
- W1982135000 cites W1892620293 @default.
- W1982135000 cites W1895538680 @default.
- W1982135000 cites W1919272385 @default.
- W1982135000 cites W1962254068 @default.
- W1982135000 cites W1963864282 @default.
- W1982135000 cites W1964203272 @default.
- W1982135000 cites W1965860934 @default.
- W1982135000 cites W1966406375 @default.
- W1982135000 cites W1966451439 @default.
- W1982135000 cites W1971684738 @default.
- W1982135000 cites W1972488785 @default.
- W1982135000 cites W1974323476 @default.
- W1982135000 cites W1974466376 @default.
- W1982135000 cites W1977180749 @default.
- W1982135000 cites W1977585036 @default.
- W1982135000 cites W1980087000 @default.
- W1982135000 cites W1983349802 @default.
- W1982135000 cites W1985168631 @default.
- W1982135000 cites W1987099311 @default.
- W1982135000 cites W1993974844 @default.
- W1982135000 cites W1997293891 @default.
- W1982135000 cites W1998088268 @default.
- W1982135000 cites W1998664055 @default.
- W1982135000 cites W1999664376 @default.
- W1982135000 cites W2000781871 @default.
- W1982135000 cites W2001020014 @default.
- W1982135000 cites W2001299015 @default.
- W1982135000 cites W2001688761 @default.
- W1982135000 cites W2002408824 @default.
- W1982135000 cites W2004602458 @default.
- W1982135000 cites W2005070116 @default.
- W1982135000 cites W2006166262 @default.
- W1982135000 cites W2006650578 @default.
- W1982135000 cites W2009088633 @default.
- W1982135000 cites W2009882167 @default.
- W1982135000 cites W2011364876 @default.
- W1982135000 cites W2018494194 @default.
- W1982135000 cites W2019334838 @default.
- W1982135000 cites W2023041575 @default.
- W1982135000 cites W2023899218 @default.
- W1982135000 cites W2025457866 @default.
- W1982135000 cites W2028657966 @default.
- W1982135000 cites W2032147816 @default.
- W1982135000 cites W2033870077 @default.
- W1982135000 cites W2034664059 @default.
- W1982135000 cites W2034897558 @default.
- W1982135000 cites W2036174860 @default.
- W1982135000 cites W2036362108 @default.
- W1982135000 cites W2036792490 @default.
- W1982135000 cites W2036831413 @default.
- W1982135000 cites W2038962904 @default.
- W1982135000 cites W2040150142 @default.
- W1982135000 cites W2041214225 @default.
- W1982135000 cites W2043392060 @default.
- W1982135000 cites W2043530153 @default.
- W1982135000 cites W2044241508 @default.
- W1982135000 cites W2045409916 @default.
- W1982135000 cites W2046054972 @default.
- W1982135000 cites W2046949772 @default.
- W1982135000 cites W2047167072 @default.
- W1982135000 cites W2047613132 @default.
- W1982135000 cites W2048674585 @default.
- W1982135000 cites W2050546176 @default.
- W1982135000 cites W2051324813 @default.
- W1982135000 cites W2052742260 @default.
- W1982135000 cites W2054236377 @default.
- W1982135000 cites W2055268621 @default.
- W1982135000 cites W2055611034 @default.
- W1982135000 cites W2055680859 @default.
- W1982135000 cites W2057042201 @default.
- W1982135000 cites W2061353398 @default.
- W1982135000 cites W2065148857 @default.
- W1982135000 cites W2068688599 @default.
- W1982135000 cites W2069121057 @default.
- W1982135000 cites W2070734601 @default.
- W1982135000 cites W2074249519 @default.
- W1982135000 cites W2077153802 @default.
- W1982135000 cites W2078380966 @default.
- W1982135000 cites W2079042103 @default.
- W1982135000 cites W2082399239 @default.
- W1982135000 cites W2083337622 @default.
- W1982135000 cites W2084979315 @default.
- W1982135000 cites W2088642279 @default.
- W1982135000 cites W2091265793 @default.
- W1982135000 cites W2095451153 @default.