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- W1982135060 abstract "To the Editor: I read with interest the discussion of Dr. Mehta[1Mehta R.L. Continuous renal replacement therapy in the critically ill patient.Kidney Int. 2005; 67: 781-795Abstract Full Text Full Text PDF PubMed Scopus (37) Google Scholar]. As “positive” findings, I see the following: (1) The treatment protocol is adapted to the widely available Prisma machine. Nevertheless, in the future I hope to see more versatile models permitting the use of other than Hospal filters, Hospal “sets,” and more flexible pump functions; (2) the recipe for citrate local anticoagulation, which reduces side effects in patients und prolongs filter function; (3) the great idea of partial predilution mode contributes, but does not resolve, problems of high volume hemodiafiltration. The focus on high blood flow should not be lost; and (4) the application of the “alternate” mode of prescription of CRRT, which hopefully will facilitate the cooperation with the intensivists. The major concern is treatment dose. When accepting the data of Ronco[2Ronco C. Bellomo R. Homel P. et al.Effects of different doses in continuous veno-venous hemofiltration on outcomes of acute renal failure: A prospective randomised trial.Lancet. 2000; 356: 26-30Abstract Full Text Full Text PDF PubMed Google Scholar], this patient is undertreated: total small molecular clearance, 37 mL/min versus 48 mL/min. Contribution of convective clearance, 25 mL/min versus 48 mL/min. Are there any hints indicating that smaller treatment doses than those of Ronco might be adequate?" @default.
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- W1982135060 date "2005-07-01" @default.
- W1982135060 modified "2023-09-30" @default.
- W1982135060 title "Continuous renal replacement therapy in the critically ill patient" @default.
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- W1982135060 doi "https://doi.org/10.1038/sj.ki.4496109" @default.
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