FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982137744> ?p ?o ?g. }

• W1982137744 endingPage "1486" @default.
• W1982137744 startingPage "1479" @default.
• W1982137744 abstract "The safety and the immunogenicity of a recombinant hybrid envelope glycoprotein MN/LAI (rgp160) followed by booster injections of a V3 (MN) linear peptide were evaluated in HIV-negative adults at low risk for HIV infection. Volunteers received either rgp160 in alum at 0, 1, and 6 months (group A), rgp160 at 0 and 1 months followed by V3 at 3 and 6 months formulated in alum (group B), or in Freund's incomplete adjuvant (FIA) (group C). Local and systemic reactions were mild to moderate and resolved within the first 72 hr after immunization. No significant biological changes (routine tests and autoantibodies) were observed. One month after the last injection in either group, neutralizing antibodies (NAs) against the HIV-1 MN isolate were detected in 4 of 5 (A), 7 of 10 (B), and 10 of 10 (C) subjects with significantly higher geometric mean titers in the latter group. Four of nine sera with the highest NA titers against MN weakly cross-neutralized the HIV-1 SF2 isolate; none had NA against the HIV-1 LAI strain or against a North American primary isolate. Specific lymphocyte T cell proliferation to rgp160 was detected in 92% of the subjects after the second injection of rgp160 and in 80% of them 12 months after the first injection. A weak and short-lived envelope-specific CD(4+)-mediated cytotoxic lymphocyte activity was detected at certain time points in few subjects. This prime-boost vaccine approach using rgp160 followed by a V3 peptide was safe in humans, and was able to elicit high levels of neutralizing antibodies and a strong and persistent T cell lymphoproliferative response to rgp160 and to V3. However, the neutralization response was restricted to the homologous HIV-1 strain and little env-specific cytotoxic activity was induced." @default.
• W1982137744 created "2016-06-24" @default.
• W1982137744 creator A5004257105 @default.
• W1982137744 creator A5014748606 @default.
• W1982137744 creator A5025598112 @default.
• W1982137744 creator A5025636369 @default.
• W1982137744 creator A5027321475 @default.
• W1982137744 creator A5031148366 @default.
• W1982137744 creator A5031869208 @default.
• W1982137744 creator A5036326331 @default.
• W1982137744 creator A5042701070 @default.
• W1982137744 creator A5044946797 @default.
• W1982137744 creator A5050254453 @default.
• W1982137744 creator A5055730290 @default.
• W1982137744 creator A5061938435 @default.
• W1982137744 creator A5074382084 @default.
• W1982137744 creator A5079512093 @default.
• W1982137744 creator A5083251507 @default.
• W1982137744 creator A5086069510 @default.
• W1982137744 date "1995-12-01" @default.
• W1982137744 modified "2023-10-18" @default.
• W1982137744 title "Safety and Immunogenicity of a Recombinant HIV Type 1 Glycoprotein 160 Boosted by a V3 Synthetic Peptide in HIV-Negative Volunteers" @default.
• W1982137744 cites W1233534743 @default.
• W1982137744 cites W1912026111 @default.
• W1982137744 cites W1982310880 @default.
• W1982137744 cites W1982794770 @default.
• W1982137744 cites W1993551508 @default.
• W1982137744 cites W1995977258 @default.
• W1982137744 cites W2016897432 @default.
• W1982137744 cites W2027570953 @default.
• W1982137744 cites W2033611972 @default.
• W1982137744 cites W2049836668 @default.
• W1982137744 cites W2051589676 @default.
• W1982137744 cites W2059161184 @default.
• W1982137744 cites W2068490834 @default.
• W1982137744 cites W2069851285 @default.
• W1982137744 cites W2082814103 @default.
• W1982137744 cites W2084341498 @default.
• W1982137744 cites W2087381265 @default.
• W1982137744 cites W2092985132 @default.
• W1982137744 cites W2102154787 @default.
• W1982137744 cites W2116372466 @default.
• W1982137744 cites W2124367359 @default.
• W1982137744 cites W2137966586 @default.
• W1982137744 cites W2155131772 @default.
• W1982137744 cites W2170908973 @default.
• W1982137744 cites W4244506835 @default.
• W1982137744 cites W4245957003 @default.
• W1982137744 doi "https://doi.org/10.1089/aid.1995.11.1479" @default.
• W1982137744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8679292" @default.
• W1982137744 hasPublicationYear "1995" @default.
• W1982137744 type Work @default.
• W1982137744 sameAs 1982137744 @default.
• W1982137744 citedByCount "28" @default.
• W1982137744 countsByYear W19821377442013 @default.
• W1982137744 countsByYear W19821377442018 @default.
• W1982137744 countsByYear W19821377442021 @default.
• W1982137744 countsByYear W19821377442023 @default.
• W1982137744 crossrefType "journal-article" @default.
• W1982137744 hasAuthorship W1982137744A5004257105 @default.
• W1982137744 hasAuthorship W1982137744A5014748606 @default.
• W1982137744 hasAuthorship W1982137744A5025598112 @default.
• W1982137744 hasAuthorship W1982137744A5025636369 @default.
• W1982137744 hasAuthorship W1982137744A5027321475 @default.
• W1982137744 hasAuthorship W1982137744A5031148366 @default.
• W1982137744 hasAuthorship W1982137744A5031869208 @default.
• W1982137744 hasAuthorship W1982137744A5036326331 @default.
• W1982137744 hasAuthorship W1982137744A5042701070 @default.
• W1982137744 hasAuthorship W1982137744A5044946797 @default.
• W1982137744 hasAuthorship W1982137744A5050254453 @default.
• W1982137744 hasAuthorship W1982137744A5055730290 @default.
• W1982137744 hasAuthorship W1982137744A5061938435 @default.
• W1982137744 hasAuthorship W1982137744A5074382084 @default.
• W1982137744 hasAuthorship W1982137744A5079512093 @default.
• W1982137744 hasAuthorship W1982137744A5083251507 @default.
• W1982137744 hasAuthorship W1982137744A5086069510 @default.
• W1982137744 hasConcept C159047783 @default.
• W1982137744 hasConcept C159654299 @default.
• W1982137744 hasConcept C203014093 @default.
• W1982137744 hasConcept C2777863537 @default.
• W1982137744 hasConcept C2780727368 @default.
• W1982137744 hasConcept C2780868878 @default.
• W1982137744 hasConcept C2910359755 @default.
• W1982137744 hasConcept C3013748606 @default.
• W1982137744 hasConcept C32611913 @default.
• W1982137744 hasConcept C86803240 @default.
• W1982137744 hasConceptScore W1982137744C159047783 @default.
• W1982137744 hasConceptScore W1982137744C159654299 @default.
• W1982137744 hasConceptScore W1982137744C203014093 @default.
• W1982137744 hasConceptScore W1982137744C2777863537 @default.
• W1982137744 hasConceptScore W1982137744C2780727368 @default.
• W1982137744 hasConceptScore W1982137744C2780868878 @default.
• W1982137744 hasConceptScore W1982137744C2910359755 @default.
• W1982137744 hasConceptScore W1982137744C3013748606 @default.
• W1982137744 hasConceptScore W1982137744C32611913 @default.
• W1982137744 hasConceptScore W1982137744C86803240 @default.
• W1982137744 hasIssue "12" @default.
• W1982137744 hasLocation W19821377441 @default.

• next