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- W1982147144 abstract "Horses were given 4 intravenous injections of morphine sulfate, 0.5 mg per kg, spaced two days apart. The motor response to morphine was measured by counting the number of steps taken with the left foreleg during a 4 minute interval at various times after the injection. By the third injection of morphine there was a significant increase in motor response. This sensitization or reverse tolerance persisted for several weeks after the last injection. Cross-sensitization also developed to the stimulant effects of apomorphine. This finding suggests that sensitization to the stimulant effects of morphine may involve dopamine receptors in the central nervous system." @default.
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- W1982147144 date "1984-01-01" @default.
- W1982147144 modified "2023-09-25" @default.
- W1982147144 title "Reverse tolerance to the stimulant effects of morphine in horses" @default.
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- W1982147144 doi "https://doi.org/10.1016/s0737-0806(84)80153-7" @default.
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