FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982149701> ?p ?o ?g. }

• W1982149701 abstract "Cardiovascular epidemiology has advanced enormously in the study of risk factors for atherosclerosis1, as evidenced by publications in Arquivos Brasileiros de Cardiologia (ABC) in the last years2-4.Based on this information, it is possible to explore new hypotheses and, therefore, new frontiers for prevention. The different perspectives for the study of these risk factors include the life course epidemiology. This perspective considers that the onset of the disease may occur long before the establishment of traditional risk factors in adulthood. Thus, health and diseases can be considered as a result of long-term effects of exposure to different factors throughout the various stages of life, including intrauterine life, childhood, adolescence and adulthood5.This significantly increases the complexity of analysis6, but also adds dimensions previously little explored in epidemiology and cardiovascular prevention. A basic concept within this line of epidemiological interpretation is that of critical or sensitive periods, that is, the idea that stimulus acting for a certain critical period of development may bring long-lasting consequences on the structure or function of organs. For example, the intrauterine period in which tissues and organs are forming, is critical for the establishment of a risk profile for the rest of the course of life. Metabolic adaptations of the fetus occurred in this period could persist for the rest of life, thus increasing the risk of chronic diseases such as coronary artery disease, diabetes and obesity during adulthood. This process has been called intrauterine programming of chronic diseases7.The ABC have been publishing interesting articles on this topic, providing insights into the discussions that have been occurring in the international arena8-10.In a study carried out in Goiânia11, the authors compared the pressures measured by ABPM, of a group of children with low birth weight with those with adequate birth weight, observing that those with underweight had higher blood pressure and abnormal circadian rhythm of blood pressure with reduced nocturnal dipping.On the other hand, Souza et al.12 studied the association between birth weight and cardiovascular risk factors in adolescents in Salvador, and observed two and a half higher prevalence of obesity and three times higher blood pressure in the group with high birth weight compared to the normal weight group.These apparently conflicting findings may actually represent a U-shaped curve, in which both low weight and high weight would represent risk over normal weight at birth. In observational studies, newborns weighing less than 2,500 g had a higher incidence of cardiovascular diseases, hypertension and atherosclerosis - and glucose intolerance, - type II diabetes or metabolic syndrome in adulthood. - Babies with birth weight higher than 4 kg, regardless of gestational age or gender, have abnormal metabolism of carbohydrates and lipids associated with later development of obesity, diabetes and dyslipidemia13-15.Besides the nonlinear association, there are many ways by which intrauterine factors can influence the pattern of disease in later stages. These effects may interact with other stimuli that occur in other periods, undergoing changes throughout life. Therefore, for example, birth weight considered in isolation would not be enough to explain the CAD. It is necessary to consider the relationship between this marker and the events following the moment of birth, such as the rapid recovery of growth in early childhood, that may further promote increased risk16,17.Therefore, the life course model supports studies on initial exposures and but their potential interaction with other intermediate factors. Gaining acquaintance with this sequence of events and with the idea of critical periods has important consequences in the adoption of preventive strategies, because it helps identify periods of increased need for intervention and helps consider social inequality in health as factors that affect the entire life cycle of many generations5.The study of Rio de Janeiro18 evaluated the blood pressure of adolescents and, again, the same individuals 18 years later. Adolescents with abnormal blood pressure in the first assessment presented higher average weight, insulin, leptin, apolipoprotein B100 and A1, the highest prevalence of overweight, obesity, increased waist circumference and hypertension in the group with normal blood pressure in adolescence. Adolescence is a phase that deserves special attention. Good nutrition during this phase permanently affects the individual's life, since in this phase, 25% of adult height and 50% of body mass are acquired. Therefore, it is an important phase for weight control and acquisition of good eating habits.Another interesting study published in ABC19 evaluated individuals at three different times in life. Adults diagnosed with metabolic syndrome presented, as early as in adolescence, significantly higher values for weight, waist circumference and body mass index. This fact has important implications for prevention, since early detection of these risk factors can mean significant benefit in the future20,21.The aThe adoption of a life course model, therefore, has the potential to significantly change the paradigm of prevention of cardiovascular diseases, of the current emphasis on control of risk factors in adulthood to a broader approach to prevention of risk factors per se throughout the course of life, including childhood and adolescence. Further Brazilian studies, including potential mechanisms, such as gene expression22, and interactions among the phases of life, body composition and environment23 may add evidence to this set, opening new possibilities of intervention in our community." @default.
• W1982149701 created "2016-06-24" @default.
• W1982149701 creator A5081891261 @default.
• W1982149701 date "2014-01-01" @default.
• W1982149701 modified "2023-10-16" @default.
• W1982149701 title "Trajectories of cardiovascular health: life course epidemiology in Brazil" @default.
• W1982149701 cites W1561913387 @default.
• W1982149701 cites W1896539819 @default.
• W1982149701 cites W1993550058 @default.
• W1982149701 cites W2004582071 @default.
• W1982149701 cites W2010165536 @default.
• W1982149701 cites W2028744383 @default.
• W1982149701 cites W2036734614 @default.
• W1982149701 cites W2052294192 @default.
• W1982149701 cites W206831310 @default.
• W1982149701 cites W2074062636 @default.
• W1982149701 cites W2075623847 @default.
• W1982149701 cites W2093882162 @default.
• W1982149701 cites W2121701258 @default.
• W1982149701 cites W2123828906 @default.
• W1982149701 cites W2124857707 @default.
• W1982149701 cites W2135693174 @default.
• W1982149701 cites W2140692939 @default.
• W1982149701 cites W2143847855 @default.
• W1982149701 cites W2158643711 @default.
• W1982149701 cites W2168195699 @default.
• W1982149701 doi "https://doi.org/10.5935/abc.20140065" @default.
• W1982149701 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4051443" @default.
• W1982149701 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24918909" @default.
• W1982149701 hasPublicationYear "2014" @default.
• W1982149701 type Work @default.
• W1982149701 sameAs 1982149701 @default.
• W1982149701 citedByCount "2" @default.
• W1982149701 countsByYear W19821497012016 @default.
• W1982149701 countsByYear W19821497012018 @default.
• W1982149701 crossrefType "journal-article" @default.
• W1982149701 hasAuthorship W1982149701A5081891261 @default.
• W1982149701 hasBestOaLocation W19821497011 @default.
• W1982149701 hasConcept C107130276 @default.
• W1982149701 hasConcept C121332964 @default.
• W1982149701 hasConcept C126322002 @default.
• W1982149701 hasConcept C1276947 @default.
• W1982149701 hasConcept C15744967 @default.
• W1982149701 hasConcept C1691868 @default.
• W1982149701 hasConcept C2777552389 @default.
• W1982149701 hasConcept C2779134260 @default.
• W1982149701 hasConcept C3018284874 @default.
• W1982149701 hasConcept C71924100 @default.
• W1982149701 hasConcept C74909509 @default.
• W1982149701 hasConcept C77805123 @default.
• W1982149701 hasConceptScore W1982149701C107130276 @default.
• W1982149701 hasConceptScore W1982149701C121332964 @default.
• W1982149701 hasConceptScore W1982149701C126322002 @default.
• W1982149701 hasConceptScore W1982149701C1276947 @default.
• W1982149701 hasConceptScore W1982149701C15744967 @default.
• W1982149701 hasConceptScore W1982149701C1691868 @default.
• W1982149701 hasConceptScore W1982149701C2777552389 @default.
• W1982149701 hasConceptScore W1982149701C2779134260 @default.
• W1982149701 hasConceptScore W1982149701C3018284874 @default.
• W1982149701 hasConceptScore W1982149701C71924100 @default.
• W1982149701 hasConceptScore W1982149701C74909509 @default.
• W1982149701 hasConceptScore W1982149701C77805123 @default.
• W1982149701 hasLocation W19821497011 @default.
• W1982149701 hasLocation W19821497012 @default.
• W1982149701 hasLocation W19821497013 @default.
• W1982149701 hasLocation W19821497014 @default.
• W1982149701 hasLocation W19821497015 @default.
• W1982149701 hasOpenAccess W1982149701 @default.
• W1982149701 hasPrimaryLocation W19821497011 @default.
• W1982149701 hasRelatedWork W1973885977 @default.
• W1982149701 hasRelatedWork W2009385780 @default.
• W1982149701 hasRelatedWork W2313111789 @default.
• W1982149701 hasRelatedWork W2317508214 @default.
• W1982149701 hasRelatedWork W2359390960 @default.
• W1982149701 hasRelatedWork W2889650027 @default.
• W1982149701 hasRelatedWork W3082623308 @default.
• W1982149701 hasRelatedWork W3120503679 @default.
• W1982149701 hasRelatedWork W4318717247 @default.
• W1982149701 hasRelatedWork W4362648715 @default.
• W1982149701 isParatext "false" @default.
• W1982149701 isRetracted "false" @default.
• W1982149701 magId "1982149701" @default.
• W1982149701 workType "article" @default.