FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W198215207> ?p ?o ?g. }

• W198215207 endingPage "6" @default.
• W198215207 startingPage "172" @default.
• W198215207 abstract "Dyslipidemia is an important factor in causation of macrovascular disease in type 2 diabetics. The role of simvastatin in the management of dyslipidemia in patients with type 2 diabetes mellitus is not very well elucidated, particularly in the context of the recent American Diabetes Association criteria 2001. The American Diabetes Association suggests that aggressive therapy of diabetic dyslipidemia will reduce the risk of coronary heart disease in diabetics and that optimal levels are serum low-density lipoprotein cholesterol <2.60 mmol/L (< 100 mg/dl), high-density lipoprotein cholesterol >1.1 5 mmol/L (>45 mg/dl) and triglycerides <2.30 mmol/L, (<200 mg/dl). This study was planned to compare the effect of simvastatin together with behavioral modification and behavioral modification alone, in age, sex and body mass index matched patients with type 2 diabetes mellitus with dyslipidemia, in reaching the target levels of various lipids as suggested by the American Diabetes Association criteria 2001.An open-label, prospective study was conducted on 80 patients with type 2 diabetes mellitus, who had fair to moderate glycemic control with a total glycated hemoglobin < 10%. The patients in the control group (n=40) were treated with only behavioral modifications like calorie control and daily walking for 30 minutes, and no lipid-lowering agent was given. The lipid profile was re-evaluated after 6 and 12 weeks. The patients in the test group (n=40) were advised behavioral modification and given simvastatin. The starting dose was 10 mg at bed time. After 6 weeks of simvastatin therapy, a lipid profile was done. If the goal of low-density lipoprotein cholesterol < 100 mg/dl and/or triglycerides <200 mg/dl and/or high-density lipoprotein cholesterol >45 mg/dl was not achieved, the dose of simvastatin was increased to 20 mg at bedtime for another 6 weeks. It was observed that low-density lipoprotein dyslipidemia was most prevalent. In the control group, a favorable alteration in lipid levels was brought about but none was statistically significant and the American Diabetes Association goals were not achieved in any of the patients. In the test group, there was a significant and favorable alteration in all lipid moieties, and the target levels were achieved in 80% of patients after 12 weeks. There was no significant alteration in glycemic control and liver functions. Myopathy and epigastric pain were seen in 1 patient in each group.In our study, behavioral modification alone did not achieve the target levels of various lipids in diabetic dyslipidemia as per the American Diabetes Association guidelines. Hence, pharmacological therapy with statins should be resorted to in patients with type 2 diabetes mellitus who carry a high risk of coronary heart disease. Simvastatin is a safe and efficacious lipid-lowering drug." @default.
• W198215207 created "2016-06-24" @default.
• W198215207 creator A5012517356 @default.
• W198215207 creator A5061776027 @default.
• W198215207 date "2001-06-29" @default.
• W198215207 modified "2023-09-26" @default.
• W198215207 title "Lipid-lowering effect of simvastatin in patients of type 2 diabetes mellitus." @default.
• W198215207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11428472" @default.
• W198215207 hasPublicationYear "2001" @default.
• W198215207 type Work @default.
• W198215207 sameAs 198215207 @default.
• W198215207 citedByCount "3" @default.
• W198215207 countsByYear W1982152072012 @default.
• W198215207 crossrefType "journal-article" @default.
• W198215207 hasAuthorship W198215207A5012517356 @default.
• W198215207 hasAuthorship W198215207A5061776027 @default.
• W198215207 hasConcept C126322002 @default.
• W198215207 hasConcept C134018914 @default.
• W198215207 hasConcept C151730666 @default.
• W198215207 hasConcept C2776329913 @default.
• W198215207 hasConcept C2777180221 @default.
• W198215207 hasConcept C2777538456 @default.
• W198215207 hasConcept C2778096610 @default.
• W198215207 hasConcept C2778270857 @default.
• W198215207 hasConcept C2779343474 @default.
• W198215207 hasConcept C2780221984 @default.
• W198215207 hasConcept C2780473172 @default.
• W198215207 hasConcept C2910068830 @default.
• W198215207 hasConcept C555293320 @default.
• W198215207 hasConcept C71924100 @default.
• W198215207 hasConcept C86803240 @default.
• W198215207 hasConcept C90924648 @default.
• W198215207 hasConceptScore W198215207C126322002 @default.
• W198215207 hasConceptScore W198215207C134018914 @default.
• W198215207 hasConceptScore W198215207C151730666 @default.
• W198215207 hasConceptScore W198215207C2776329913 @default.
• W198215207 hasConceptScore W198215207C2777180221 @default.
• W198215207 hasConceptScore W198215207C2777538456 @default.
• W198215207 hasConceptScore W198215207C2778096610 @default.
• W198215207 hasConceptScore W198215207C2778270857 @default.
• W198215207 hasConceptScore W198215207C2779343474 @default.
• W198215207 hasConceptScore W198215207C2780221984 @default.
• W198215207 hasConceptScore W198215207C2780473172 @default.
• W198215207 hasConceptScore W198215207C2910068830 @default.
• W198215207 hasConceptScore W198215207C555293320 @default.
• W198215207 hasConceptScore W198215207C71924100 @default.
• W198215207 hasConceptScore W198215207C86803240 @default.
• W198215207 hasConceptScore W198215207C90924648 @default.
• W198215207 hasIssue "2" @default.
• W198215207 hasLocation W1982152071 @default.
• W198215207 hasOpenAccess W198215207 @default.
• W198215207 hasPrimaryLocation W1982152071 @default.
• W198215207 hasRelatedWork W198215207 @default.
• W198215207 hasRelatedWork W2310858462 @default.
• W198215207 hasRelatedWork W2470362524 @default.
• W198215207 hasRelatedWork W2522154672 @default.
• W198215207 hasRelatedWork W2580321811 @default.
• W198215207 hasRelatedWork W2891139845 @default.
• W198215207 hasRelatedWork W2896249438 @default.
• W198215207 hasRelatedWork W3134393320 @default.
• W198215207 hasRelatedWork W2186471480 @default.
• W198215207 hasRelatedWork W2990766464 @default.
• W198215207 hasVolume "53" @default.
• W198215207 isParatext "false" @default.
• W198215207 isRetracted "false" @default.
• W198215207 magId "198215207" @default.
• W198215207 workType "article" @default.