FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982156600> ?p ?o ?g. }

• W1982156600 endingPage "31" @default.
• W1982156600 startingPage "24" @default.
• W1982156600 abstract "Intercellular adhesion molecule-1 (ICAM-1) expression is a necessary requirement for leucocyte/keratinocyte interactions, and keratinocyte upregulation of ICAM-1 is seen in several inflammatory dermatoses. While keratinocytes have a very low constitutive expression of ICAM-1, they can be induced to upregulate ICAM-1 in response to several inflammatory cytokines, such as interferon-gamma (IFN gamma). There is some evidence to suggest that the state of keratinocyte differentiation may influence the level of ICAM-1 expression induced by IFN gamma. The purpose of this study was to investigate the hypothesis that keratinocytes, as they differentiate, may lose their ability to increase their expression of ICAM-1 in response to IFN gamma. Keratinocytes from 13 donors were cultured under conditions which either permitted (Green's medium) or inhibited (MCDB153) differentiation. The ICAM-1 expression in response to IFN gamma was assessed by a sensitive, cell-based, ELISA, and related to the state of differentiation of the cells (as assessed by a quantitative assay for involucrin). While keratinocytes grown in MCDB153 remained responsive to IFN gamma throughout 4 days of culture, the response of keratinocytes grown in Green's medium progressively decreased, so that, by day 3, only a high concentration of IFN gamma (500 U/ml) led to a significant increase in ICAM-1 expression. After 4 days in culture, no upregulation of ICAM-1 was seen. The deterioration in the response of Green's-cultured keratinocytes to IFN gamma mirrored an increase in their expression of involucrin in parallel cultures. Overall, our data demonstrate a progressive loss in the ability of keratinocytes to upregulate ICAM-1 in response to IFN gamma, which is associated with differentiation of these cells. This would support the view that only basal proliferative keratinocytes are responsive to inflammatory cytokines, and play a part in the initiation and amplification of inflammatory reactions in vivo." @default.
• W1982156600 created "2016-06-24" @default.
• W1982156600 creator A5028170694 @default.
• W1982156600 creator A5076841474 @default.
• W1982156600 creator A5082549110 @default.
• W1982156600 date "1996-07-01" @default.
• W1982156600 modified "2023-09-23" @default.
• W1982156600 title "Differentiation of human keratinocytes is associated with a progressive loss of interferon gamma-induced intercellular adhesion molecule-1 expression." @default.
• W1982156600 cites W1550039558 @default.
• W1982156600 cites W1650036545 @default.
• W1982156600 cites W1977779461 @default.
• W1982156600 cites W1997255839 @default.
• W1982156600 cites W2004454060 @default.
• W1982156600 cites W2007027096 @default.
• W1982156600 cites W2010358369 @default.
• W1982156600 cites W2010963898 @default.
• W1982156600 cites W2018517153 @default.
• W1982156600 cites W2019049870 @default.
• W1982156600 cites W2024797632 @default.
• W1982156600 cites W2028967881 @default.
• W1982156600 cites W2029786286 @default.
• W1982156600 cites W2036075088 @default.
• W1982156600 cites W2037532439 @default.
• W1982156600 cites W2042477744 @default.
• W1982156600 cites W2045934824 @default.
• W1982156600 cites W2047625438 @default.
• W1982156600 cites W2049043712 @default.
• W1982156600 cites W2052598717 @default.
• W1982156600 cites W2057559338 @default.
• W1982156600 cites W2057784785 @default.
• W1982156600 cites W2059435029 @default.
• W1982156600 cites W2069053176 @default.
• W1982156600 cites W2074029723 @default.
• W1982156600 cites W2079748356 @default.
• W1982156600 cites W2090169073 @default.
• W1982156600 cites W2090344792 @default.
• W1982156600 cites W2092830320 @default.
• W1982156600 cites W2122334788 @default.
• W1982156600 cites W2127016872 @default.
• W1982156600 cites W2415027341 @default.
• W1982156600 cites W80775301 @default.
• W1982156600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8776354" @default.
• W1982156600 hasPublicationYear "1996" @default.
• W1982156600 type Work @default.
• W1982156600 sameAs 1982156600 @default.
• W1982156600 citedByCount "5" @default.
• W1982156600 countsByYear W19821566002012 @default.
• W1982156600 crossrefType "journal-article" @default.
• W1982156600 hasAuthorship W1982156600A5028170694 @default.
• W1982156600 hasAuthorship W1982156600A5076841474 @default.
• W1982156600 hasAuthorship W1982156600A5082549110 @default.
• W1982156600 hasConcept C104317684 @default.
• W1982156600 hasConcept C127561419 @default.
• W1982156600 hasConcept C148738053 @default.
• W1982156600 hasConcept C153911025 @default.
• W1982156600 hasConcept C16224149 @default.
• W1982156600 hasConcept C185946421 @default.
• W1982156600 hasConcept C203014093 @default.
• W1982156600 hasConcept C2777074287 @default.
• W1982156600 hasConcept C2777577635 @default.
• W1982156600 hasConcept C2778690821 @default.
• W1982156600 hasConcept C2780841837 @default.
• W1982156600 hasConcept C2909375385 @default.
• W1982156600 hasConcept C54355233 @default.
• W1982156600 hasConcept C55493867 @default.
• W1982156600 hasConcept C79879829 @default.
• W1982156600 hasConcept C81885089 @default.
• W1982156600 hasConcept C86803240 @default.
• W1982156600 hasConcept C95444343 @default.
• W1982156600 hasConceptScore W1982156600C104317684 @default.
• W1982156600 hasConceptScore W1982156600C127561419 @default.
• W1982156600 hasConceptScore W1982156600C148738053 @default.
• W1982156600 hasConceptScore W1982156600C153911025 @default.
• W1982156600 hasConceptScore W1982156600C16224149 @default.
• W1982156600 hasConceptScore W1982156600C185946421 @default.
• W1982156600 hasConceptScore W1982156600C203014093 @default.
• W1982156600 hasConceptScore W1982156600C2777074287 @default.
• W1982156600 hasConceptScore W1982156600C2777577635 @default.
• W1982156600 hasConceptScore W1982156600C2778690821 @default.
• W1982156600 hasConceptScore W1982156600C2780841837 @default.
• W1982156600 hasConceptScore W1982156600C2909375385 @default.
• W1982156600 hasConceptScore W1982156600C54355233 @default.
• W1982156600 hasConceptScore W1982156600C55493867 @default.
• W1982156600 hasConceptScore W1982156600C79879829 @default.
• W1982156600 hasConceptScore W1982156600C81885089 @default.
• W1982156600 hasConceptScore W1982156600C86803240 @default.
• W1982156600 hasConceptScore W1982156600C95444343 @default.
• W1982156600 hasIssue "1" @default.
• W1982156600 hasLocation W19821566001 @default.
• W1982156600 hasOpenAccess W1982156600 @default.
• W1982156600 hasPrimaryLocation W19821566001 @default.
• W1982156600 hasRelatedWork W1974422506 @default.
• W1982156600 hasRelatedWork W1982156600 @default.
• W1982156600 hasRelatedWork W1983779673 @default.
• W1982156600 hasRelatedWork W1996454042 @default.
• W1982156600 hasRelatedWork W1997255839 @default.
• W1982156600 hasRelatedWork W2003410806 @default.
• W1982156600 hasRelatedWork W2057559338 @default.

• next