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• W1982159551 abstract "Dysfunction of endothelial cells is considered a major cause of vascular complications in diabetes. In the present study, we investigated the protective effect of Padina arborescens extract against high glucose-induced oxidative damage in human umbilical vein endothelial cells (HUVECs). High-concentration of glucose (30 mM) treatment induced cytotoxicity whereas Padina arborescens extract protected the cells from high glucose-induced damage and significantly restored cell viability. In addition, lipid peroxidation, intracellular reactive oxygen species (ROS), and nitric oxide (NO) levels induced by high glucose treatment were effectively inhibited by treatment of Padina arborescens extract in a dose-dependent manner. High glucose treatment also induced the overexpressions of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and NF-κB proteins in HUVECs, but Padina arborescens extract treatment reduced the over-expressions of these proteins. These findings indicate the potential benefits of Padina arborescens extract as a valuable source in reducing the oxidative damage induced by high glucose." @default.
• W1982159551 created "2016-06-24" @default.
• W1982159551 creator A5021319454 @default.
• W1982159551 creator A5068964888 @default.
• W1982159551 date "2013-03-31" @default.
• W1982159551 modified "2023-09-26" @default.
• W1982159551 title "Protective Effect of Padina arborescens Extract against High Glucose-induced Oxidative Damage in Human Umbilical Vein Endothelial Cells" @default.
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• W1982159551 doi "https://doi.org/10.3746/pnf.2013.18.1.011" @default.
• W1982159551 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3867148" @default.
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