FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982160131> ?p ?o ?g. }

• W1982160131 endingPage "710" @default.
• W1982160131 startingPage "699" @default.
• W1982160131 abstract "Abstract Contact between T cells and APCs and activation of an effective immune response trigger cellular polarization and the formation of a structured interface known as the immunological synapse. Interactions across the synapse and secretion of T cell and APC-derived factors into the perisynaptic compartment regulate synapse formation and activation of T cells. We report that the serine protease inhibitor neuroserpin, an axonally secreted protein thought to play roles in the formation of the neuronal synapse and refinement of synaptic activity, is expressed in human nai¨ve effector memory and central memory subsets of CD4+ and CD8+ T cells, as well as monocytes, B cells, and NK cells. Neuroserpin partially colocalized with a TGN38/LFA-1-positive vesicle population in T cells and translocates to the immunological synapse upon activation with TCR antibodies or antigen-pulsed APCs. Activation of T cells triggered neuroserpin secretion, a rapid, 8.4-fold up-regulation of the serine protease tissue plasminogen activator, the protease target for neuroserpin, and a delayed, 6.25-fold down-regulation of neuroserpin expression. Evidence of polarization and regulated neuroserpin expression was also seen in ex vivo analyses of human lymph nodes and blood-derived T cells. Increased neuroserpin expression was seen in clusters of T cells in the paracortex of human lymph nodes, with some showing polarization to areas of cell:cell interaction. Our results support a role for neuroserpin and tissue plasminogen activator in activation-controlled proteolytic cleavage of proteins in the synaptic or perisynaptic space to modulate immune cell function." @default.
• W1982160131 created "2016-06-24" @default.
• W1982160131 creator A5012608451 @default.
• W1982160131 creator A5015466003 @default.
• W1982160131 creator A5016318576 @default.
• W1982160131 creator A5018618347 @default.
• W1982160131 creator A5021856789 @default.
• W1982160131 creator A5022058325 @default.
• W1982160131 creator A5040805579 @default.
• W1982160131 creator A5068901580 @default.
• W1982160131 creator A5085716089 @default.
• W1982160131 date "2015-02-10" @default.
• W1982160131 modified "2023-09-27" @default.
• W1982160131 title "Human T cell activation induces synaptic translocation and alters expression of the serine protease inhibitor neuroserpin and its target protease" @default.
• W1982160131 cites W1562441478 @default.
• W1982160131 cites W1809964664 @default.
• W1982160131 cites W1855403496 @default.
• W1982160131 cites W1898680880 @default.
• W1982160131 cites W1973164213 @default.
• W1982160131 cites W1973268693 @default.
• W1982160131 cites W1974138271 @default.
• W1982160131 cites W1984415601 @default.
• W1982160131 cites W1987240796 @default.
• W1982160131 cites W1988193334 @default.
• W1982160131 cites W1989706412 @default.
• W1982160131 cites W1993371622 @default.
• W1982160131 cites W1998809715 @default.
• W1982160131 cites W2002085644 @default.
• W1982160131 cites W2009517326 @default.
• W1982160131 cites W2012727559 @default.
• W1982160131 cites W2013776818 @default.
• W1982160131 cites W2016011680 @default.
• W1982160131 cites W2016460112 @default.
• W1982160131 cites W2021657931 @default.
• W1982160131 cites W2028623574 @default.
• W1982160131 cites W2041046304 @default.
• W1982160131 cites W2042904225 @default.
• W1982160131 cites W2046355418 @default.
• W1982160131 cites W2055302622 @default.
• W1982160131 cites W2056207883 @default.
• W1982160131 cites W2056442885 @default.
• W1982160131 cites W2056685423 @default.
• W1982160131 cites W2058689904 @default.
• W1982160131 cites W2061851108 @default.
• W1982160131 cites W2066236445 @default.
• W1982160131 cites W2068005505 @default.
• W1982160131 cites W2070919467 @default.
• W1982160131 cites W2081214901 @default.
• W1982160131 cites W2081473560 @default.
• W1982160131 cites W2084601195 @default.
• W1982160131 cites W2090661916 @default.
• W1982160131 cites W2090740497 @default.
• W1982160131 cites W2101513390 @default.
• W1982160131 cites W2105592881 @default.
• W1982160131 cites W2107363136 @default.
• W1982160131 cites W2108767527 @default.
• W1982160131 cites W2123600404 @default.
• W1982160131 cites W2124077382 @default.
• W1982160131 cites W2124733101 @default.
• W1982160131 cites W2125686203 @default.
• W1982160131 cites W2125782175 @default.
• W1982160131 cites W2127424425 @default.
• W1982160131 cites W2133535940 @default.
• W1982160131 cites W2135449612 @default.
• W1982160131 cites W2144885248 @default.
• W1982160131 cites W2144967224 @default.
• W1982160131 cites W2145386430 @default.
• W1982160131 cites W2149744477 @default.
• W1982160131 cites W2159474332 @default.
• W1982160131 cites W2169628793 @default.
• W1982160131 cites W4211044652 @default.
• W1982160131 cites W4321429204 @default.
• W1982160131 doi "https://doi.org/10.1189/jlb.1a0814-392r" @default.
• W1982160131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25670787" @default.
• W1982160131 hasPublicationYear "2015" @default.
• W1982160131 type Work @default.
• W1982160131 sameAs 1982160131 @default.
• W1982160131 citedByCount "14" @default.
• W1982160131 countsByYear W19821601312016 @default.
• W1982160131 countsByYear W19821601312017 @default.
• W1982160131 countsByYear W19821601312019 @default.
• W1982160131 countsByYear W19821601312021 @default.
• W1982160131 countsByYear W19821601312022 @default.
• W1982160131 countsByYear W19821601312023 @default.
• W1982160131 crossrefType "journal-article" @default.
• W1982160131 hasAuthorship W1982160131A5012608451 @default.
• W1982160131 hasAuthorship W1982160131A5015466003 @default.
• W1982160131 hasAuthorship W1982160131A5016318576 @default.
• W1982160131 hasAuthorship W1982160131A5018618347 @default.
• W1982160131 hasAuthorship W1982160131A5021856789 @default.
• W1982160131 hasAuthorship W1982160131A5022058325 @default.
• W1982160131 hasAuthorship W1982160131A5040805579 @default.
• W1982160131 hasAuthorship W1982160131A5068901580 @default.
• W1982160131 hasAuthorship W1982160131A5085716089 @default.
• W1982160131 hasConcept C181199279 @default.
• W1982160131 hasConcept C19317047 @default.
• W1982160131 hasConcept C203014093 @default.
• W1982160131 hasConcept C2776090121 @default.

• next