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- W1982160168 abstract "In this note, we highlight the fact that the choice of type I and type II error rates should not simply be set at traditional levels in the phase II clinical trial setting when considering the relative success rate of previous trials in a given disease setting. For diseases in which it is rare that a new compound is active, we argue that more stringent type I error rates in the phase II setting may be more important relative to relaxing the type II error rates. The paper itself is more of a 'thought' experiment on this topic such that specific clinical trial settings will require specific applications of this approach. This is due in part to the fact that the real-world setting is more complex relative to overall decision process in terms of moving from phase II to phase III trials than our basic illustrative model." @default.
- W1982160168 created "2016-06-24" @default.
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- W1982160168 date "2012-01-11" @default.
- W1982160168 modified "2023-10-18" @default.
- W1982160168 title "An examination of the relative impact of type I and type II error rates in phase II drug screening trial queues." @default.
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- W1982160168 doi "https://doi.org/10.1002/pst.529" @default.
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