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• W1982160718 endingPage "220" @default.
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• W1982160718 abstract "Decreases in the mitochondrial content of Fe-S proteins appear to cause a loss of bioenergetic functions in skeletal muscle mitochondria during dietary iron deficiency. Following 21 days of an iron-deficient diet (2 mg iron/kg), significant decreases in muscle mitochondrial iron protein content, dehydrogenase and oxidase activities, and rates of ATP synthesis were observed relative to rats fed a control diet (50 mg iron/kg). Fe-S proteins were studied by EPR spectroscopy at low temperatures, following incubation with substrates, and/or redox titrations. Submitochondrial preparations were utilized in order to overcome membrane barriers to electron donors and to concentrate inner mitochondrial membrane Fe-S proteins. The Fe-S proteins of rat muscle mitochondria (not previously studied) appear remarkably similar to those of other tissues and species. Although the concentration of most Fe-S proteins studied was decreased by iron deficiency, the Rieske cluster of Complex III (Fe-Sbc-1) was only minimally affected. In Complex II, Fe-S cluster S-1 was decreased 38% and cluster S-3 was decreased 59%. Complex I Fe-S clusters were substantially decreased by iron deficiency. The Fe-S cluster of electron-transferring flavoprotein dehydrogenase was 55% lower in the iron-deficient submitochondrial preparations. Succinate and NADH dehydrogenase activities, and maximal rates of reversed electron transport were about 80% lower in iron-deficient submitochondrial preparations than in controls, and oxidase activities were decreased about 70%. Decreases in cytochrome content were too small to explain loss of oxidase activity, and clearly could not affect dehydrogenases or reversed electron transport. Despite reductions in maximal rates of ATP formation, the efficiency of phosphorylative coupling was not affected. Our studies suggest that the loss of Fe-S clusters causes decreases in the dehydrogenase activities and that the iron depletion from the complexes is not a random process." @default.
• W1982160718 created "2016-06-24" @default.
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• W1982160718 date "1982-02-01" @default.
• W1982160718 modified "2023-09-26" @default.
• W1982160718 title "Effects of dietary iron deficiency on iron-sulfur proteins and bioenergetic functions of skeletal muscle mitochondria" @default.
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• W1982160718 doi "https://doi.org/10.1016/0005-2728(82)90292-4" @default.
• W1982160718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7059584" @default.
• W1982160718 hasPublicationYear "1982" @default.
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