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- W1982161730 abstract "It has been hypothesized that misfolded tau protein could be a mediator of the inflammatory response in human tauopathies. Here we show that neurodegenerative lesions caused by human truncated tau promote inflammatory response manifested by upregulation of immune-molecules (CD11a,b, CD18, CD4, CD45 and CD68) and morphological activation of microglial cells in a rat model of tauopathy. In parallel, the innate immune brain response promotes activation of MHC class II positive blood-borne leukocytes and their influx into the brain parenchyma. These findings have important consequences for the rationale drug development of effective inflammation-based therapeutic strategies for human tauopathies." @default.
- W1982161730 created "2016-06-24" @default.
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- W1982161730 date "2009-04-01" @default.
- W1982161730 modified "2023-10-16" @default.
- W1982161730 title "Human misfolded truncated tau protein promotes activation of microglia and leukocyte infiltration in the transgenic rat model of tauopathy" @default.
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- W1982161730 doi "https://doi.org/10.1016/j.jneuroim.2009.01.013" @default.
- W1982161730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19232747" @default.
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