FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982163978> ?p ?o ?g. }

• W1982163978 endingPage "472" @default.
• W1982163978 startingPage "466" @default.
• W1982163978 abstract "The proteolytic degradation of hypoxia inducible factor (HIF)α by the von Hippel–Lindau (VHL) tumour suppressor protein (pVHL) has emerged as a key cellular mechanism for the control of adaptive gene expression programmes in response to changes in oxygen levels. The inactivation of this mechanism is phenotypically depicted by the vascular nature of VHL-associated tumours and has also recently been associated with the processes of invasion and metastasis. However, the complex genotype–phenotype correlations, which are a hallmark of VHL disease, demonstrate that the function of pVHL is likely to extend beyond its crucial role in oxygen signal transduction and might include roles for pVHL in the regulation of microtubule dynamics, cell polarity and directed cell migration. Further studies aimed at defining the normal function of VHL in these processes will help to identify the molecular mechanisms underlying pVHL-associated tumourigenesis. The proteolytic degradation of hypoxia inducible factor (HIF)α by the von Hippel–Lindau (VHL) tumour suppressor protein (pVHL) has emerged as a key cellular mechanism for the control of adaptive gene expression programmes in response to changes in oxygen levels. The inactivation of this mechanism is phenotypically depicted by the vascular nature of VHL-associated tumours and has also recently been associated with the processes of invasion and metastasis. However, the complex genotype–phenotype correlations, which are a hallmark of VHL disease, demonstrate that the function of pVHL is likely to extend beyond its crucial role in oxygen signal transduction and might include roles for pVHL in the regulation of microtubule dynamics, cell polarity and directed cell migration. Further studies aimed at defining the normal function of VHL in these processes will help to identify the molecular mechanisms underlying pVHL-associated tumourigenesis." @default.
• W1982163978 created "2016-06-24" @default.
• W1982163978 creator A5053701690 @default.
• W1982163978 creator A5057674895 @default.
• W1982163978 date "2004-09-01" @default.
• W1982163978 modified "2023-10-11" @default.
• W1982163978 title "The von Hippel–Lindau tumour suppressor: a multi-faceted inhibitor of tumourigenesis" @default.
• W1982163978 cites W1578283200 @default.
• W1982163978 cites W1749022239 @default.
• W1982163978 cites W1963533810 @default.
• W1982163978 cites W1968972540 @default.
• W1982163978 cites W1970078605 @default.
• W1982163978 cites W1972009030 @default.
• W1982163978 cites W1973092951 @default.
• W1982163978 cites W1973233564 @default.
• W1982163978 cites W1978583875 @default.
• W1982163978 cites W1979446481 @default.
• W1982163978 cites W1980371364 @default.
• W1982163978 cites W1980475208 @default.
• W1982163978 cites W1989183186 @default.
• W1982163978 cites W1990923495 @default.
• W1982163978 cites W1995392909 @default.
• W1982163978 cites W2000573201 @default.
• W1982163978 cites W2002375694 @default.
• W1982163978 cites W2002897207 @default.
• W1982163978 cites W2005868568 @default.
• W1982163978 cites W2006622472 @default.
• W1982163978 cites W2011497948 @default.
• W1982163978 cites W2013818100 @default.
• W1982163978 cites W2015042023 @default.
• W1982163978 cites W2018235962 @default.
• W1982163978 cites W2022694136 @default.
• W1982163978 cites W2023952710 @default.
• W1982163978 cites W2031485253 @default.
• W1982163978 cites W2054633892 @default.
• W1982163978 cites W2060104085 @default.
• W1982163978 cites W2067324420 @default.
• W1982163978 cites W2072227408 @default.
• W1982163978 cites W2077858999 @default.
• W1982163978 cites W2086812941 @default.
• W1982163978 cites W2089692551 @default.
• W1982163978 cites W2093776019 @default.
• W1982163978 cites W2094242056 @default.
• W1982163978 cites W2103173315 @default.
• W1982163978 cites W2106590335 @default.
• W1982163978 cites W2117250040 @default.
• W1982163978 cites W2123724520 @default.
• W1982163978 cites W2127314317 @default.
• W1982163978 cites W2129621205 @default.
• W1982163978 cites W2129889907 @default.
• W1982163978 cites W2139354324 @default.
• W1982163978 cites W2140496726 @default.
• W1982163978 cites W2141275515 @default.
• W1982163978 cites W2148160363 @default.
• W1982163978 cites W2152294869 @default.
• W1982163978 cites W2156323704 @default.
• W1982163978 cites W2158957516 @default.
• W1982163978 cites W2170734841 @default.
• W1982163978 cites W2170801131 @default.
• W1982163978 cites W2312955998 @default.
• W1982163978 cites W2319855134 @default.
• W1982163978 cites W2551569844 @default.
• W1982163978 cites W3022518945 @default.
• W1982163978 cites W4244190676 @default.
• W1982163978 cites W4323874277 @default.
• W1982163978 cites W68397822 @default.
• W1982163978 doi "https://doi.org/10.1016/j.molmed.2004.07.008" @default.
• W1982163978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15350900" @default.
• W1982163978 hasPublicationYear "2004" @default.
• W1982163978 type Work @default.
• W1982163978 sameAs 1982163978 @default.
• W1982163978 citedByCount "61" @default.
• W1982163978 countsByYear W19821639782012 @default.
• W1982163978 countsByYear W19821639782013 @default.
• W1982163978 countsByYear W19821639782014 @default.
• W1982163978 countsByYear W19821639782015 @default.
• W1982163978 countsByYear W19821639782017 @default.
• W1982163978 countsByYear W19821639782018 @default.
• W1982163978 countsByYear W19821639782019 @default.
• W1982163978 countsByYear W19821639782020 @default.
• W1982163978 countsByYear W19821639782021 @default.
• W1982163978 countsByYear W19821639782022 @default.
• W1982163978 countsByYear W19821639782023 @default.
• W1982163978 crossrefType "journal-article" @default.
• W1982163978 hasAuthorship W1982163978A5053701690 @default.
• W1982163978 hasAuthorship W1982163978A5057674895 @default.
• W1982163978 hasConcept C104317684 @default.
• W1982163978 hasConcept C127716648 @default.
• W1982163978 hasConcept C160450060 @default.
• W1982163978 hasConcept C179185449 @default.
• W1982163978 hasConcept C20418707 @default.
• W1982163978 hasConcept C502942594 @default.
• W1982163978 hasConcept C54355233 @default.
• W1982163978 hasConcept C62478195 @default.
• W1982163978 hasConcept C86803240 @default.
• W1982163978 hasConcept C95444343 @default.
• W1982163978 hasConceptScore W1982163978C104317684 @default.
• W1982163978 hasConceptScore W1982163978C127716648 @default.

• next