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- W1982168327 abstract "Tumor necrosis factor-α TNF-α), interleukin-1 (IL-1), and interferon alpha (IFN-α) stimulate hepatic lipogenesis in vivo. We now show that TNF-α, IL-1, and IFN-α stimulate lipogenesis as measured by the incorporation of 3H-glycerol into triglyceride in cultured HepG2 cells. Incubation of HepG2 cells for approximately 24 hours with TNF or IL-1 was required to see stimulation of lipogenesis, with this effect increasing over the next four days. TNF stimulated lipogenesis by 2.4-fold after 72 hours of incubation, while a 3.5-fold stimulation was seen with IL-1. The half maximal concentration for TNF stimulation of hepatic lipogenesis was 4 ng/mL, while that for IL-1 was 0.3 ng/mL. Cells treated with TNF or IL-1 also showed increased secretion of labeled triglyceride into the media. IFN-α stimulated the incorporation of 3H-glycerol into triglyceride by 39% after 72 hour's incubation. In contrast, IFN-γ had no effect on lipogenesis in HepG2 cells. These data suggest that cytokines can directly stimulate the synthesis of triglycerides in cultured Hep G2 liver cells in vitro." @default.
- W1982168327 created "2016-06-24" @default.
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- W1982168327 date "1991-09-01" @default.
- W1982168327 modified "2023-10-16" @default.
- W1982168327 title "Tumor necrosis factor-α, interleukin-1, and interferon alpha stimulate triglyceride synthesis in HepG2 cells" @default.
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- W1982168327 doi "https://doi.org/10.1016/0026-0495(91)90062-2" @default.
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