FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982169105> ?p ?o ?g. }

• W1982169105 abstract "Trogocytosis is defined as the transfer of cell-surface membrane proteins and membrane patches from one cell to another through contact. It is reported that human epidermal growth factor receptor 2 (HER2) could be transferred from cancer cells to monocytes via trogocytosis; however, the clinical significance of this is unknown. The aim of this study is to demonstrate the presence and evaluate the clinical significance of HER2(+) tumor-infiltrated immune cells (arising through HER2 trogocytosis) in HER2-overexpressing (HER2+) breast cancer patients receiving trastuzumab-based primary systemic therapy (PST).To assess the trogocytosis of HER2 from cancer cells to immune cells, and to evaluate the up- and down-regulation of HER2 on immune and cancer cells, peripheral blood mononuclear cells from healthy volunteers and breast cancer patients were co-cultured with HER2+ and HER2-negative breast cancer cell lines with and without trastuzumab, respectively. The correlation between HER2 expression on tumor-infiltrated immune cells and a pathological complete response (pCR) in HER2+ breast cancer patients treated with trastuzumab-based PST was analyzed.HER2 was transferred from HER2+ breast cancer cells to monocytes and natural killer cells by trogocytosis. Trastuzumab-mediated trogocytosed-HER2(+) effector cells exhibited greater CD107a expression than non-HER2-trogocytosed effector cells. In breast cancer patients, HER2 expression on tumor-infiltrated immune cells in treatment naïve HER2+ tumors was associated with a pCR to trastuzumab-based PST.HER2-trogocytosis is visible evidence of tumor microenvironment interaction between cancer cells and immune cells. Given that effective contact between these cells is critical for immune destruction of target cancer cells, this interaction is of great significance. It is possible that HER2 trogocytosis could be used as a predictive biomarker for trastuzumab-based PST efficacy in HER2(+) breast cancer patients." @default.
• W1982169105 created "2016-06-24" @default.
• W1982169105 creator A5000647160 @default.
• W1982169105 creator A5016907831 @default.
• W1982169105 creator A5019917934 @default.
• W1982169105 creator A5028439535 @default.
• W1982169105 creator A5038803108 @default.
• W1982169105 creator A5044707802 @default.
• W1982169105 creator A5062729944 @default.
• W1982169105 date "2015-02-06" @default.
• W1982169105 modified "2023-10-16" @default.
• W1982169105 title "Trogocytosis-mediated expression of HER2 on immune cells may be associated with a pathological complete response to trastuzumab-based primary systemic therapy in HER2-overexpressing breast cancer patients" @default.
• W1982169105 cites W1610114835 @default.
• W1982169105 cites W1972811164 @default.
• W1982169105 cites W1996299884 @default.
• W1982169105 cites W2000424215 @default.
• W1982169105 cites W2020881982 @default.
• W1982169105 cites W2023681515 @default.
• W1982169105 cites W2029166421 @default.
• W1982169105 cites W2038072276 @default.
• W1982169105 cites W2040935952 @default.
• W1982169105 cites W2041134224 @default.
• W1982169105 cites W2053662475 @default.
• W1982169105 cites W2057793212 @default.
• W1982169105 cites W2058141973 @default.
• W1982169105 cites W2067271905 @default.
• W1982169105 cites W2069307120 @default.
• W1982169105 cites W2076121010 @default.
• W1982169105 cites W2100527196 @default.
• W1982169105 cites W2115672176 @default.
• W1982169105 cites W2118600609 @default.
• W1982169105 cites W2120431466 @default.
• W1982169105 cites W2131912399 @default.
• W1982169105 cites W2137471841 @default.
• W1982169105 cites W2144124503 @default.
• W1982169105 cites W2146384083 @default.
• W1982169105 cites W2147761019 @default.
• W1982169105 cites W2149908785 @default.
• W1982169105 cites W2167207914 @default.
• W1982169105 cites W2313168486 @default.
• W1982169105 doi "https://doi.org/10.1186/s12885-015-1041-3" @default.
• W1982169105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4329225" @default.
• W1982169105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25655677" @default.
• W1982169105 hasPublicationYear "2015" @default.
• W1982169105 type Work @default.
• W1982169105 sameAs 1982169105 @default.
• W1982169105 citedByCount "13" @default.
• W1982169105 countsByYear W19821691052015 @default.
• W1982169105 countsByYear W19821691052016 @default.
• W1982169105 countsByYear W19821691052017 @default.
• W1982169105 countsByYear W19821691052018 @default.
• W1982169105 countsByYear W19821691052021 @default.
• W1982169105 countsByYear W19821691052022 @default.
• W1982169105 countsByYear W19821691052023 @default.
• W1982169105 crossrefType "journal-article" @default.
• W1982169105 hasAuthorship W1982169105A5000647160 @default.
• W1982169105 hasAuthorship W1982169105A5016907831 @default.
• W1982169105 hasAuthorship W1982169105A5019917934 @default.
• W1982169105 hasAuthorship W1982169105A5028439535 @default.
• W1982169105 hasAuthorship W1982169105A5038803108 @default.
• W1982169105 hasAuthorship W1982169105A5044707802 @default.
• W1982169105 hasAuthorship W1982169105A5062729944 @default.
• W1982169105 hasBestOaLocation W19821691051 @default.
• W1982169105 hasConcept C121608353 @default.
• W1982169105 hasConcept C126322002 @default.
• W1982169105 hasConcept C203014093 @default.
• W1982169105 hasConcept C2776107976 @default.
• W1982169105 hasConcept C2779786085 @default.
• W1982169105 hasConcept C502942594 @default.
• W1982169105 hasConcept C530470458 @default.
• W1982169105 hasConcept C71924100 @default.
• W1982169105 hasConcept C8891405 @default.
• W1982169105 hasConcept C96232424 @default.
• W1982169105 hasConceptScore W1982169105C121608353 @default.
• W1982169105 hasConceptScore W1982169105C126322002 @default.
• W1982169105 hasConceptScore W1982169105C203014093 @default.
• W1982169105 hasConceptScore W1982169105C2776107976 @default.
• W1982169105 hasConceptScore W1982169105C2779786085 @default.
• W1982169105 hasConceptScore W1982169105C502942594 @default.
• W1982169105 hasConceptScore W1982169105C530470458 @default.
• W1982169105 hasConceptScore W1982169105C71924100 @default.
• W1982169105 hasConceptScore W1982169105C8891405 @default.
• W1982169105 hasConceptScore W1982169105C96232424 @default.
• W1982169105 hasIssue "1" @default.
• W1982169105 hasLocation W19821691051 @default.
• W1982169105 hasLocation W19821691052 @default.
• W1982169105 hasLocation W19821691053 @default.
• W1982169105 hasLocation W19821691054 @default.
• W1982169105 hasLocation W19821691055 @default.
• W1982169105 hasOpenAccess W1982169105 @default.
• W1982169105 hasPrimaryLocation W19821691051 @default.
• W1982169105 hasRelatedWork W2771066073 @default.
• W1982169105 hasRelatedWork W2809831584 @default.
• W1982169105 hasRelatedWork W2991909253 @default.
• W1982169105 hasRelatedWork W3024956345 @default.
• W1982169105 hasRelatedWork W3161615519 @default.
• W1982169105 hasRelatedWork W4248193217 @default.
• W1982169105 hasRelatedWork W4283731173 @default.
• W1982169105 hasRelatedWork W4291367166 @default.
• W1982169105 hasRelatedWork W4307036171 @default.

• next