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- W1982172600 abstract "Objective: In the setting of essential hypertension, scarce data exist regarding the associations between retinal vascular alterations and cardiac remodeling process. The aim of our study was to evaluate the link between fundus vascular changes and echocardiographically derived parameters of cardiac maladaptation. Design and Method: Our study population consisted of 229 stage I-II untreated essential hypertensive subjects (aged 62 ± 10 years, 120 female, office blood pressure 155 ± 92 mmHg), free of clinically evident cardiovascular disease. All participants underwent routine blood test analysis, 24 hour ambulatory blood pressure monitoring (ABPM), complete echocardiographic study and fundoscopy examination. The subjects were divided into five categories according to Scheie's fundus grading system of severity (0, I, II, III, IV: normal, arteriolar narrowing, arteriovenous nipping, hemorrhages-exudates and pappiloedema respectively). Results: The five groups did not differ concerning age, sex, basic ABPM parameters, as well as their metabolic profile (fasting glucose, serum lipids, uric acid). Deterioration of the retinal vascular category was associated with a statistically significant impairment of ejection fraction (63% ± 2 vs 61% ± 1.8 vs 60.3% ± 2.2 vs 58.2% ± 1.5 vs 56.1% ± 2.4, respectively, p = 0.01) accompanied by an increase in interventricular septum endiastolic thickness (9.9 ± 0.24 vs 10 ± 0.28 vs 10.3 ± 0.35 vs 10.4 ± 0.4 vs 10.7 ± 0.45 mm, respectively, p = 0.013) and left atrial anteroposterior diameter (37 ± 0.7 vs 39.11 ± 1.1 vs 39.26 ± 1.2 vs 41.06 ± 1.31 vs 42.01 ± 1.53 mm, p = 0.029). On the contrary, the five categories did not differ regarding left atrial volume (p = 0.287), left atrial volume index (p = 0.319) and posterior wall endiastolic thickness (p = 0.232). Conclusions: In essential hypertensive patients, progressive escalation of fundus vasculature damage is accompanied by commensurate left atrial and ventricular remodeling, as well as respective global impairement of left venticular systolic function." @default.
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- W1982172600 date "2010-06-01" @default.
- W1982172600 modified "2023-09-26" @default.
- W1982172600 title "RETINAL VASCULAR DAMAGE AND CARDIAC REMODELING IN ESSENTIAL HYPERTENSION: A TALE OF PARALLEL ESCALATION: PP.35.445" @default.
- W1982172600 doi "https://doi.org/10.1097/01.hjh.0000379983.44380.18" @default.
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