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• W1982173655 abstract "Maintenance of the stem cell population in the C. elegans germline requires GLP-1/Notch signaling. We show that this signaling inhibits the accumulation of the RNA binding protein GLD-1. In a genetic screen to identify other genes involved in regulating GLD-1 activity, we identified mutations in the nos-3 gene, the protein product of which is similar to the Drosophila translational regulator Nanos. Our data demonstrate that nos-3 promotes GLD-1 accumulation redundantly with gld-2, and that nos-3 functions genetically downstream or parallel to fbf, an inhibitor of GLD-1 translation. We show that the GLD-1 accumulation pattern is important in controlling the proliferation versus meiotic development decision, with low GLD-1 levels allowing proliferation and increased levels promoting meiotic entry." @default.
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• W1982173655 date "2004-01-01" @default.
• W1982173655 modified "2023-09-25" @default.
• W1982173655 title "Control of the proliferation versus meiotic development decision in the<i>C. elegans</i>germline through regulation of GLD-1 protein accumulation" @default.
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• W1982173655 doi "https://doi.org/10.1242/dev.00916" @default.
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