FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982175090> ?p ?o ?g. }

• W1982175090 endingPage "12" @default.
• W1982175090 startingPage "8" @default.
• W1982175090 abstract "As documented in the recent OECD report ‘the adverse outcome pathway for skin sensitisation initiated by covalent binding to proteins’ (OECD, 2012), the chemical and biological events driving the induction of human skin sensitisation have been investigated for many years and are now well understood. Several non-animal test methods have been developed to predict sensitiser potential by measuring the impact of chemical sensitisers on these key events (Adler et al., 2011; Maxwell et al., 2011); however our ability to use these non-animal datasets for risk assessment decision-making (i.e. to establish a safe level of human exposure for a sensitising chemical) remains limited and a more mechanistic approach to data integration is required to address this challenge. Informed by our previous efforts to model the induction of skin sensitisation (Maxwell and MacKay, 2008) we are now developing two mathematical models (‘total haptenated protein’ model and ‘CD8+ T cell response’ model) that will be linked to provide predictions of the human CD8+ T cell response for a defined skin exposure to a sensitising chemical. Mathematical model development is underpinned by focussed clinical or human-relevant research activities designed to inform/challenge model predictions whilst also increasing our fundamental understanding of human skin sensitisation. With this approach, we aim to quantify the relationship between the dose of sensitiser applied to the skin and the extent of the hapten-specific T cell response that would result. Furthermore, by benchmarking our mathematical model predictions against clinical datasets (e.g. human diagnostic patch test data), instead of animal test data, we propose that this approach could represent a new paradigm for mechanistic toxicology." @default.
• W1982175090 created "2016-06-24" @default.
• W1982175090 creator A5007566164 @default.
• W1982175090 creator A5012819778 @default.
• W1982175090 creator A5017796153 @default.
• W1982175090 creator A5024582311 @default.
• W1982175090 creator A5027698070 @default.
• W1982175090 creator A5030275661 @default.
• W1982175090 creator A5035023722 @default.
• W1982175090 creator A5039678961 @default.
• W1982175090 creator A5049731546 @default.
• W1982175090 creator A5053895948 @default.
• W1982175090 creator A5064111564 @default.
• W1982175090 creator A5065145337 @default.
• W1982175090 creator A5072928250 @default.
• W1982175090 creator A5081391738 @default.
• W1982175090 date "2014-02-01" @default.
• W1982175090 modified "2023-10-13" @default.
• W1982175090 title "Applying the skin sensitisation adverse outcome pathway (AOP) to quantitative risk assessment" @default.
• W1982175090 cites W1235029393 @default.
• W1982175090 cites W1507800008 @default.
• W1982175090 cites W1561210178 @default.
• W1982175090 cites W1971201122 @default.
• W1982175090 cites W1977392400 @default.
• W1982175090 cites W1979029958 @default.
• W1982175090 cites W2000541955 @default.
• W1982175090 cites W2008643614 @default.
• W1982175090 cites W2012663457 @default.
• W1982175090 cites W2021117487 @default.
• W1982175090 cites W2028324232 @default.
• W1982175090 cites W2029128444 @default.
• W1982175090 cites W2031473244 @default.
• W1982175090 cites W2033378993 @default.
• W1982175090 cites W2059252070 @default.
• W1982175090 cites W2062663311 @default.
• W1982175090 cites W2084694949 @default.
• W1982175090 cites W2092028991 @default.
• W1982175090 cites W2116712689 @default.
• W1982175090 cites W2119359019 @default.
• W1982175090 cites W2127213687 @default.
• W1982175090 cites W2127676159 @default.
• W1982175090 cites W2129166192 @default.
• W1982175090 cites W2130446440 @default.
• W1982175090 cites W2149974098 @default.
• W1982175090 cites W2334927069 @default.
• W1982175090 doi "https://doi.org/10.1016/j.tiv.2013.10.013" @default.
• W1982175090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24184331" @default.
• W1982175090 hasPublicationYear "2014" @default.
• W1982175090 type Work @default.
• W1982175090 sameAs 1982175090 @default.
• W1982175090 citedByCount "56" @default.
• W1982175090 countsByYear W19821750902014 @default.
• W1982175090 countsByYear W19821750902015 @default.
• W1982175090 countsByYear W19821750902016 @default.
• W1982175090 countsByYear W19821750902017 @default.
• W1982175090 countsByYear W19821750902018 @default.
• W1982175090 countsByYear W19821750902019 @default.
• W1982175090 countsByYear W19821750902020 @default.
• W1982175090 countsByYear W19821750902022 @default.
• W1982175090 countsByYear W19821750902023 @default.
• W1982175090 crossrefType "journal-article" @default.
• W1982175090 hasAuthorship W1982175090A5007566164 @default.
• W1982175090 hasAuthorship W1982175090A5012819778 @default.
• W1982175090 hasAuthorship W1982175090A5017796153 @default.
• W1982175090 hasAuthorship W1982175090A5024582311 @default.
• W1982175090 hasAuthorship W1982175090A5027698070 @default.
• W1982175090 hasAuthorship W1982175090A5030275661 @default.
• W1982175090 hasAuthorship W1982175090A5035023722 @default.
• W1982175090 hasAuthorship W1982175090A5039678961 @default.
• W1982175090 hasAuthorship W1982175090A5049731546 @default.
• W1982175090 hasAuthorship W1982175090A5053895948 @default.
• W1982175090 hasAuthorship W1982175090A5064111564 @default.
• W1982175090 hasAuthorship W1982175090A5065145337 @default.
• W1982175090 hasAuthorship W1982175090A5072928250 @default.
• W1982175090 hasAuthorship W1982175090A5081391738 @default.
• W1982175090 hasConcept C12174686 @default.
• W1982175090 hasConcept C134018914 @default.
• W1982175090 hasConcept C144133560 @default.
• W1982175090 hasConcept C162853370 @default.
• W1982175090 hasConcept C197934379 @default.
• W1982175090 hasConcept C203014093 @default.
• W1982175090 hasConcept C2776217527 @default.
• W1982175090 hasConcept C2777459323 @default.
• W1982175090 hasConcept C2778117688 @default.
• W1982175090 hasConcept C2910206359 @default.
• W1982175090 hasConcept C3018346242 @default.
• W1982175090 hasConcept C33070731 @default.
• W1982175090 hasConcept C38652104 @default.
• W1982175090 hasConcept C41008148 @default.
• W1982175090 hasConcept C54355233 @default.
• W1982175090 hasConcept C70721500 @default.
• W1982175090 hasConcept C71924100 @default.
• W1982175090 hasConcept C86251818 @default.
• W1982175090 hasConcept C86803240 @default.
• W1982175090 hasConcept C98274493 @default.
• W1982175090 hasConceptScore W1982175090C12174686 @default.
• W1982175090 hasConceptScore W1982175090C134018914 @default.
• W1982175090 hasConceptScore W1982175090C144133560 @default.

• next