Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982178587> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W1982178587 endingPage "2640" @default.
- W1982178587 startingPage "2631" @default.
- W1982178587 abstract "The mechanisms for the progression of the anthracycline-induced cardiomyopathy to contractile failure has not been defined.In vitro, doxorubicin (DOX) appears to modify calcium-mediated excitation–contraction coupling, which depresses cardiac contractility. This study characterizes the onset of contractile failure associated with the development of DOX-induced cardiomyopathy. Rabbits were treated with DOX (1 mg/kg i.v. twice weekly, 12–18 doses; DOX-treated group) and compared with a pair-fed Control group infuse with saline vehicle. The severity of the cardiomyopathy was determined by numerically-scored histopathology. Myocardial contractility was determined in thin fiber bundles from right ventricular (RV) papillary muscles and left atria that were removed and mounted on a force transducer in oxygenated Krebs-bicarbonate buffer (pH=7.4 at 30°C) to record the amplitude (DT) and maximum rate (+dT/dt) of isometric tension. Myofibrillar and calcium loading properties were determined by the calcium and caffeine-activated tension responses respectively in chemically-permeabilized fibers. With the onset of the cardiomyopathy (score <2) DT at low frequency (0.5 Hz) was depressed (0.61±0.01 mN/mg;n=14) compared to Control (0.93±0.09 mN/mg;n=15). Contractility at higher rates (1 Hz) was not different in this DOX-treated and Control groups. Maximum calcium and caffeine-activated force and the pCa to half-maximum force of permeabilized fibers were comparable in DOX-treated and Control groups. The loss of contractility of the DOX-treated group was related to reduction in sacroplasmic reticulum calcium release channel density, as determined by Bmaxfor3H-ryanodine binding in cardiac microsomal membrane fraction. Post-rest potentiation of contractility, as well as frequency-dependent (0.25–1.5 Hz) and post-extrasystolic potentiation of contractility were preserved in the DOX-treated group.In vitro, DOX depressed post-rest potentiation of contractility. Thus, the onset of contractile failure of the DOX-induced cardiomyopathy is characterized by effects consistent with disordered calcium-mediated excitation–contraction coupling and these effects are qualitatively different thanin vitroeffects of DOX." @default.
- W1982178587 created "2016-06-24" @default.
- W1982178587 creator A5002348205 @default.
- W1982178587 creator A5003524256 @default.
- W1982178587 creator A5040842957 @default.
- W1982178587 creator A5041065705 @default.
- W1982178587 creator A5050865228 @default.
- W1982178587 date "1997-10-01" @default.
- W1982178587 modified "2023-09-25" @default.
- W1982178587 title "Contractile Failure in Chronic Doxorubicin-induced Cardiomyopathy" @default.
- W1982178587 cites W1439349072 @default.
- W1982178587 cites W1503019013 @default.
- W1982178587 cites W1557449322 @default.
- W1982178587 cites W1565417780 @default.
- W1982178587 cites W1791262955 @default.
- W1982178587 cites W1895562635 @default.
- W1982178587 cites W1985100637 @default.
- W1982178587 cites W1996423501 @default.
- W1982178587 cites W2001148888 @default.
- W1982178587 cites W2008824074 @default.
- W1982178587 cites W2031984123 @default.
- W1982178587 cites W2078144987 @default.
- W1982178587 cites W2080116661 @default.
- W1982178587 cites W2084569850 @default.
- W1982178587 cites W2118147972 @default.
- W1982178587 cites W2138427708 @default.
- W1982178587 cites W2977097895 @default.
- W1982178587 cites W62003040 @default.
- W1982178587 cites W81539916 @default.
- W1982178587 doi "https://doi.org/10.1006/jmcc.1997.0494" @default.
- W1982178587 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9344758" @default.
- W1982178587 hasPublicationYear "1997" @default.
- W1982178587 type Work @default.
- W1982178587 sameAs 1982178587 @default.
- W1982178587 citedByCount "46" @default.
- W1982178587 countsByYear W19821785872012 @default.
- W1982178587 countsByYear W19821785872013 @default.
- W1982178587 countsByYear W19821785872014 @default.
- W1982178587 countsByYear W19821785872015 @default.
- W1982178587 countsByYear W19821785872016 @default.
- W1982178587 countsByYear W19821785872018 @default.
- W1982178587 countsByYear W19821785872020 @default.
- W1982178587 countsByYear W19821785872022 @default.
- W1982178587 crossrefType "journal-article" @default.
- W1982178587 hasAuthorship W1982178587A5002348205 @default.
- W1982178587 hasAuthorship W1982178587A5003524256 @default.
- W1982178587 hasAuthorship W1982178587A5040842957 @default.
- W1982178587 hasAuthorship W1982178587A5041065705 @default.
- W1982178587 hasAuthorship W1982178587A5050865228 @default.
- W1982178587 hasConcept C126322002 @default.
- W1982178587 hasConcept C134018914 @default.
- W1982178587 hasConcept C164705383 @default.
- W1982178587 hasConcept C185592680 @default.
- W1982178587 hasConcept C2778198053 @default.
- W1982178587 hasConcept C2778797674 @default.
- W1982178587 hasConcept C39133596 @default.
- W1982178587 hasConcept C519063684 @default.
- W1982178587 hasConcept C71924100 @default.
- W1982178587 hasConcept C7301908 @default.
- W1982178587 hasConceptScore W1982178587C126322002 @default.
- W1982178587 hasConceptScore W1982178587C134018914 @default.
- W1982178587 hasConceptScore W1982178587C164705383 @default.
- W1982178587 hasConceptScore W1982178587C185592680 @default.
- W1982178587 hasConceptScore W1982178587C2778198053 @default.
- W1982178587 hasConceptScore W1982178587C2778797674 @default.
- W1982178587 hasConceptScore W1982178587C39133596 @default.
- W1982178587 hasConceptScore W1982178587C519063684 @default.
- W1982178587 hasConceptScore W1982178587C71924100 @default.
- W1982178587 hasConceptScore W1982178587C7301908 @default.
- W1982178587 hasIssue "10" @default.
- W1982178587 hasLocation W19821785871 @default.
- W1982178587 hasLocation W19821785872 @default.
- W1982178587 hasOpenAccess W1982178587 @default.
- W1982178587 hasPrimaryLocation W19821785871 @default.
- W1982178587 hasRelatedWork W1247827509 @default.
- W1982178587 hasRelatedWork W2003842308 @default.
- W1982178587 hasRelatedWork W2064236298 @default.
- W1982178587 hasRelatedWork W2095093072 @default.
- W1982178587 hasRelatedWork W2157162729 @default.
- W1982178587 hasRelatedWork W2208998902 @default.
- W1982178587 hasRelatedWork W2428249168 @default.
- W1982178587 hasRelatedWork W2748952813 @default.
- W1982178587 hasRelatedWork W2778960539 @default.
- W1982178587 hasRelatedWork W4241372022 @default.
- W1982178587 hasVolume "29" @default.
- W1982178587 isParatext "false" @default.
- W1982178587 isRetracted "false" @default.
- W1982178587 magId "1982178587" @default.
- W1982178587 workType "article" @default.