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- W1982179255 abstract "Adult mice were injected intraperitoneally with a single dose of 3.5 mg/kg or 0.35 mg/kg of reserpine, and the effect of reserpine on glycogen in the choroidal epithelial cells was studied with the light and electron microscopes. A large dose of reserpine induced a prominent transient accumulation of glycogen in the choroidal epithelial cells. In the telencephalic and myelencephalic choroid plexuses, a small amount of glycogen appeared at 3 h after reserpine injection and increased gradually until 12 h. At 24 h, however, the glycogen content was decreased and at 36 h and later glycogen was no longer visible. In the choroid plexus of the third ventricle, the amount of glycogen deposition was slightly smaller, and it first appeared somewhat later and persisted longer. A small dose of reserpine could cause an increase in glycogen content in the choroidal epithelial cells of the telencephalic and myelencephalic plexuses but not in those of the diencephalic plexus. When nialamide, a monoamine oxidase inhibitor, had been given prior to reserpine, the effect of reserpine was abolished. Electron microscopy revealed that in mice treated with reserpine, the stored glycogen in the choroidal epithelial cells appeared in the form of beta-particles and that no appreciable changes were seen in cytological details of the epithelial cells. The effect of reserpine on the choroidal epithelial cells was discussed in relation to a possible mechanism of action of reserpine." @default.
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- W1982179255 date "1974-04-01" @default.
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- W1982179255 title "Reserpine-induced glycogen accumulation in the epithelial cells of the mouse choroid plexus" @default.
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- W1982179255 doi "https://doi.org/10.1016/0006-8993(74)90216-9" @default.
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