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• W1982181307 abstract "A human erythroleukemia (HEL) cell line was used as a model to study dynamic changes in human 12-, 15-, 5-lipoxygenases, five lipoxygenase activating protein (FLAP), and leukotriene A4 (LTA4) hydrolase gene expression during megakaryocytic differentiation induced by diosgenin (Beneytout, J.L, Nappez, C., Leboutet, M.J. and Malinvaud, G., Biochem. Biophys. Res. Commun., 207 (1995) 398–404). The study was performed at the transcriptional level: 12- and 5-lipoxygenase mRNAs, FLAP mRNA and LTA4 hydrolase mRNA were detected before and after diosgenin treatment in HEL cells while 15-lipoxygenase mRNA was undetected. When HEL cells were incubated with arachidonic acid, 5-, 12-, 15-hydroxyeicosatetraenoic acids (HETE) and LTC4 were synthesized. In contrast, the diosgenin treatment induced the suppression of 12-lipoxygenase activity and only 5-, 15-HETEs and LTC4 were synthesized." @default.
• W1982181307 created "2016-06-24" @default.
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• W1982181307 date "1995-09-01" @default.
• W1982181307 modified "2023-09-25" @default.
• W1982181307 title "Changes in lipoxygenase activities in human erythroleukemia (HEL) cells during diosgenin-induced differentiation" @default.
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• W1982181307 doi "https://doi.org/10.1016/0304-3835(95)03923-k" @default.
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• W1982181307 hasPublicationYear "1995" @default.
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