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• W1982181504 abstract "Antisense technology holds tremendous promise for therapeutic applications and the study of gene function. A broadly applicable route of administration that would provide for non-invasive, simple, and convenient delivery is highly desirable. Application of oligonucleotides to the skin may represent a solution to the delivery question for both local treatment of skin disease and for systemic delivery. The iontophoretic mode of delivery for phosphorothioate oligonucleotides across hairless mouse skin reveals the potential limitation in the delivery of sufficient oligonucleotide to provide for efficacy. A potential solution to this problem is the use of significantly more potent C-5 propyne base modifications in a phosphorothioate oligonucleotide. The combination of the iontophoretic delivery mode with potent oligonucleotides resulted in selective inhibition of the CYP3A2 gene expression in the rat liver. Alternatively, oligomers with neutral charge combined with passive modes of transdermal delivery may also be feasible and represent an even more broadly applicable technology. Future studies will focus on specific applications of local and systemic therapy of antisense oligonucleotide in animal models for the design of treatment regimens." @default.
• W1982181504 created "2016-06-24" @default.
• W1982181504 creator A5022864117 @default.
• W1982181504 creator A5082192456 @default.
• W1982181504 date "2000-10-01" @default.
• W1982181504 modified "2023-10-16" @default.
• W1982181504 title "Transdermal delivery of antisense compounds" @default.
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• W1982181504 doi "https://doi.org/10.1016/s0169-409x(00)00083-1" @default.
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