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- W1982182110 abstract "In vitro disintegration tests have served as a control procedure in the production of uniform tableted products. These tests do not necessarily reflect the true in vivo disintegration of the tablet. A major factor which may be responsible is the effect of the thick, viscous, adhesive mucous which is constantly being produced within the alimentary tract. Disintegration values for a variety of tablets were determined in U. S. P. simulated gastric juice and in human gastric juice. In addition, these tablets were exposed to gastric mucous obtained from human subjects and then evaluated for disintegration properties in simulated gastric juice. Exposure to mucous for periods of three to five minutes significantly lengthened the disintegration time." @default.
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- W1982182110 date "1959-01-01" @default.
- W1982182110 modified "2023-09-26" @default.
- W1982182110 title "A Preliminary Report of the Effect of Gastric Mucous upon Tablet Disintegration**LaWall and Harrisson Research Laboratories, Philadelphia, Pa." @default.
- W1982182110 cites W1563049182 @default.
- W1982182110 doi "https://doi.org/10.1002/jps.3030480108" @default.
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