FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982183299> ?p ?o ?g. }

• W1982183299 endingPage "159" @default.
• W1982183299 startingPage "155" @default.
• W1982183299 abstract "Wortmannin has been shown to be a non‐competitive and irreversible inhibitor of PI3 kinase. For this reason, it has attracted considerable interest and it has been used, as a selective inhibitor of the PI3 kinase, for the study of signal transduction pathways in different systems including Xenopus oocytes. We show here that wortmannin itself is able to induce meiotic maturation at doses slightly higher that those required for complete inhibition of PI3 kinase. This effect was shown to be independent of the ability to inhibit PI3K since another unrelated PI3K inhibitor, LY294002, was unable to induce oocyte maturation at inhibitory concentrations for PI3 kinase. The mechanism for wortmannin‐induced maturation involves the activation of maturation promoting factor (MPF) and MAP kinase activities in a time course that preceded the appearance of germinal vesicle breakdown. Thus, the pathway activated by wortmannin directly or indirectly affects other protein or proteins, besides PI3 kinase, responsible for its activity. This new target is placed independently or downstream of the PI3 kinase inhibition and upstream of protein synthesis. Moreover, the inhibition of either MPF or cAMP phosphodiesterase blocks wortmannin‐induced maturation. We conclude that wortmannin may be a valuable tool for the study of the pathway leading to mitotic maturation of oocytes, but cannot be used as a specific PI3 kinase inhibitor." @default.
• W1982183299 created "2016-06-24" @default.
• W1982183299 creator A5054941477 @default.
• W1982183299 creator A5063985660 @default.
• W1982183299 date "1998-01-30" @default.
• W1982183299 modified "2023-10-13" @default.
• W1982183299 title "Wortmannin, an inhibitor of phosphatidyl‐inositol 3‐kinase, induces oocyte maturation through a MPF‐MAPK‐dependent pathway" @default.
• W1982183299 cites W1493270933 @default.
• W1982183299 cites W1513878541 @default.
• W1982183299 cites W1524849287 @default.
• W1982183299 cites W1528368632 @default.
• W1982183299 cites W1543868967 @default.
• W1982183299 cites W1601079227 @default.
• W1982183299 cites W1602103287 @default.
• W1982183299 cites W1712871378 @default.
• W1982183299 cites W1818313483 @default.
• W1982183299 cites W1969442037 @default.
• W1982183299 cites W1984269514 @default.
• W1982183299 cites W1992529920 @default.
• W1982183299 cites W1997316859 @default.
• W1982183299 cites W2012130857 @default.
• W1982183299 cites W2013549179 @default.
• W1982183299 cites W2015902966 @default.
• W1982183299 cites W2018636110 @default.
• W1982183299 cites W2021509469 @default.
• W1982183299 cites W2023640845 @default.
• W1982183299 cites W2025781389 @default.
• W1982183299 cites W2025794474 @default.
• W1982183299 cites W2026663492 @default.
• W1982183299 cites W2038458124 @default.
• W1982183299 cites W2047759998 @default.
• W1982183299 cites W2074065842 @default.
• W1982183299 cites W2078564480 @default.
• W1982183299 cites W2080263723 @default.
• W1982183299 cites W2085668133 @default.
• W1982183299 cites W2092583350 @default.
• W1982183299 cites W2113131917 @default.
• W1982183299 cites W2118728598 @default.
• W1982183299 cites W2124541962 @default.
• W1982183299 cites W2132203777 @default.
• W1982183299 cites W2143225526 @default.
• W1982183299 cites W2204025208 @default.
• W1982183299 cites W2257494122 @default.
• W1982183299 cites W2281226559 @default.
• W1982183299 cites W2412701519 @default.
• W1982183299 cites W247355068 @default.
• W1982183299 cites W278881652 @default.
• W1982183299 cites W66625613 @default.
• W1982183299 doi "https://doi.org/10.1016/s0014-5793(97)01619-0" @default.
• W1982183299 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9489996" @default.
• W1982183299 hasPublicationYear "1998" @default.
• W1982183299 type Work @default.
• W1982183299 sameAs 1982183299 @default.
• W1982183299 citedByCount "19" @default.
• W1982183299 countsByYear W19821832992012 @default.
• W1982183299 countsByYear W19821832992013 @default.
• W1982183299 countsByYear W19821832992020 @default.
• W1982183299 crossrefType "journal-article" @default.
• W1982183299 hasAuthorship W1982183299A5054941477 @default.
• W1982183299 hasAuthorship W1982183299A5063985660 @default.
• W1982183299 hasBestOaLocation W19821832991 @default.
• W1982183299 hasConcept C120089663 @default.
• W1982183299 hasConcept C184235292 @default.
• W1982183299 hasConcept C185592680 @default.
• W1982183299 hasConcept C190283241 @default.
• W1982183299 hasConcept C196843134 @default.
• W1982183299 hasConcept C2776690073 @default.
• W1982183299 hasConcept C2776912716 @default.
• W1982183299 hasConcept C2778308172 @default.
• W1982183299 hasConcept C2780610907 @default.
• W1982183299 hasConcept C2781322055 @default.
• W1982183299 hasConcept C29537977 @default.
• W1982183299 hasConcept C2994119143 @default.
• W1982183299 hasConcept C55493867 @default.
• W1982183299 hasConcept C62478195 @default.
• W1982183299 hasConcept C6902291 @default.
• W1982183299 hasConcept C86554907 @default.
• W1982183299 hasConcept C86803240 @default.
• W1982183299 hasConcept C95444343 @default.
• W1982183299 hasConcept C97029542 @default.
• W1982183299 hasConceptScore W1982183299C120089663 @default.
• W1982183299 hasConceptScore W1982183299C184235292 @default.
• W1982183299 hasConceptScore W1982183299C185592680 @default.
• W1982183299 hasConceptScore W1982183299C190283241 @default.
• W1982183299 hasConceptScore W1982183299C196843134 @default.
• W1982183299 hasConceptScore W1982183299C2776690073 @default.
• W1982183299 hasConceptScore W1982183299C2776912716 @default.
• W1982183299 hasConceptScore W1982183299C2778308172 @default.
• W1982183299 hasConceptScore W1982183299C2780610907 @default.
• W1982183299 hasConceptScore W1982183299C2781322055 @default.
• W1982183299 hasConceptScore W1982183299C29537977 @default.
• W1982183299 hasConceptScore W1982183299C2994119143 @default.
• W1982183299 hasConceptScore W1982183299C55493867 @default.
• W1982183299 hasConceptScore W1982183299C62478195 @default.
• W1982183299 hasConceptScore W1982183299C6902291 @default.
• W1982183299 hasConceptScore W1982183299C86554907 @default.
• W1982183299 hasConceptScore W1982183299C86803240 @default.
• W1982183299 hasConceptScore W1982183299C95444343 @default.

• next