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• W1982183410 startingPage "5578" @default.
• W1982183410 abstract "On the basis of the observation that the central side effects of MAO inhibitors may represent a major limit for their use in pathological processes involving peripheral MAOs, we investigated the possibility of generating novel inhibitors able to target specifically peripheral MAOs. To address this issue, we designed compounds 7−28. From biological results, the 2-(5-phenyl-furan-2-yl)-4,5-dihydro-1H-imidazole (Furaline, 17) proved to be a suitable lead. In fact, in enzyme assays on homogenate preparation from rat liver and HEK cells expressing MAO-A or MAO-B, compounds possessing the frame of 17 behaved as selective and reversible MAO-A inhibitors. Interestingly, in in vivo studies the amino derivative 21 (Amifuraline), endowed with good hydrophilic character, was able to significantly inhibit liver but not brain MAO-A." @default.
• W1982183410 created "2016-06-24" @default.
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• W1982183410 date "2006-08-01" @default.
• W1982183410 modified "2023-10-18" @default.
• W1982183410 title "3-[5-(4,5-Dihydro-1<i>H</i>-imidazol-2-yl)-furan-2-yl]phenylamine (Amifuraline), a Promising Reversible and Selective Peripheral MAO-A Inhibitor" @default.
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• W1982183410 doi "https://doi.org/10.1021/jm060605r" @default.
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