Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982184546> ?p ?o ?g. }
- W1982184546 endingPage "477" @default.
- W1982184546 startingPage "466" @default.
- W1982184546 abstract "Long-term immunosuppressed renal transplant recipients with chronic hepatitis B virus (HBV) infection often develop liver cirrhosis (LC) and end-stage liver disease (ESLD). This study investigated accumulation and persistence of specific HBV mutants in relation to the clinical course in these patients (n = 38; mean follow-up, 3.5 years). HBV was analyzed longitudinally via length polymorphism of polymerase chain reaction (PCR) fragments (median, 6.5 serum samples per patient) as well as by cloning and partial sequencing of 346 full-length HBV genomes. Fourteen patients (group 1) developed LC or died from ESLD, whereas 24 patients (group 2) showed no evidence of LC during follow-up. Development of LC and ESLD was associated with persistence of HBV mutant populations characterized by deletions/insertions in core promoter plus deletions in the C gene and/or deletions in the pre-S region (86% of group 1 vs. 17% of group 2; P < .0001). HBV without these mutations or with core promoter mutations alone were predominantly found in group 2 (14% of group 1 vs. 75% of group 2). In patients infected with core promoter mutants, the additional appearance and persistence of deletions in the C gene and/or the pre-S region were accompanied or followed by development of LC and ESLD. The mutations were distributed on individual genomes in various combinations, leading to a high complexity of the virus population. In conclusion, these data suggest that accumulation and persistence of specific HBV populations characterized by mutations in 3 subgenomic regions play a role in pathogenesis of LC and ESLD in long-term renal transplant recipients." @default.
- W1982184546 created "2016-06-24" @default.
- W1982184546 creator A5003606092 @default.
- W1982184546 creator A5009238529 @default.
- W1982184546 creator A5051191695 @default.
- W1982184546 creator A5051235946 @default.
- W1982184546 creator A5051640970 @default.
- W1982184546 creator A5060425510 @default.
- W1982184546 creator A5068282089 @default.
- W1982184546 creator A5083753728 @default.
- W1982184546 date "2002-02-01" @default.
- W1982184546 modified "2023-10-16" @default.
- W1982184546 title "Complex HBV populations with mutations in core promoter, C gene, and pre-S region are associated with development of cirrhosis in long-term renal transplant recipients" @default.
- W1982184546 cites W1511984367 @default.
- W1982184546 cites W1518945847 @default.
- W1982184546 cites W1530383201 @default.
- W1982184546 cites W1577658470 @default.
- W1982184546 cites W1608204833 @default.
- W1982184546 cites W1611884612 @default.
- W1982184546 cites W1784997902 @default.
- W1982184546 cites W1876057216 @default.
- W1982184546 cites W1932591551 @default.
- W1982184546 cites W1964140685 @default.
- W1982184546 cites W1976990630 @default.
- W1982184546 cites W1977520603 @default.
- W1982184546 cites W1991228857 @default.
- W1982184546 cites W2017347114 @default.
- W1982184546 cites W2029155127 @default.
- W1982184546 cites W2049496890 @default.
- W1982184546 cites W2054968862 @default.
- W1982184546 cites W2060640351 @default.
- W1982184546 cites W2066945643 @default.
- W1982184546 cites W2068574509 @default.
- W1982184546 cites W2072683836 @default.
- W1982184546 cites W2081647927 @default.
- W1982184546 cites W2082415486 @default.
- W1982184546 cites W2092138793 @default.
- W1982184546 cites W2111995033 @default.
- W1982184546 cites W2118365585 @default.
- W1982184546 cites W2119220259 @default.
- W1982184546 cites W2119809710 @default.
- W1982184546 cites W2131993508 @default.
- W1982184546 cites W2142328414 @default.
- W1982184546 cites W2156552801 @default.
- W1982184546 cites W2158129085 @default.
- W1982184546 doi "https://doi.org/10.1053/jhep.2002.30698" @default.
- W1982184546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11826424" @default.
- W1982184546 hasPublicationYear "2002" @default.
- W1982184546 type Work @default.
- W1982184546 sameAs 1982184546 @default.
- W1982184546 citedByCount "80" @default.
- W1982184546 countsByYear W19821845462012 @default.
- W1982184546 countsByYear W19821845462013 @default.
- W1982184546 countsByYear W19821845462014 @default.
- W1982184546 countsByYear W19821845462015 @default.
- W1982184546 countsByYear W19821845462016 @default.
- W1982184546 countsByYear W19821845462017 @default.
- W1982184546 countsByYear W19821845462018 @default.
- W1982184546 countsByYear W19821845462020 @default.
- W1982184546 countsByYear W19821845462021 @default.
- W1982184546 countsByYear W19821845462022 @default.
- W1982184546 crossrefType "journal-article" @default.
- W1982184546 hasAuthorship W1982184546A5003606092 @default.
- W1982184546 hasAuthorship W1982184546A5009238529 @default.
- W1982184546 hasAuthorship W1982184546A5051191695 @default.
- W1982184546 hasAuthorship W1982184546A5051235946 @default.
- W1982184546 hasAuthorship W1982184546A5051640970 @default.
- W1982184546 hasAuthorship W1982184546A5060425510 @default.
- W1982184546 hasAuthorship W1982184546A5068282089 @default.
- W1982184546 hasAuthorship W1982184546A5083753728 @default.
- W1982184546 hasBestOaLocation W19821845461 @default.
- W1982184546 hasConcept C101762097 @default.
- W1982184546 hasConcept C104317684 @default.
- W1982184546 hasConcept C126322002 @default.
- W1982184546 hasConcept C143065580 @default.
- W1982184546 hasConcept C150194340 @default.
- W1982184546 hasConcept C159047783 @default.
- W1982184546 hasConcept C2522874641 @default.
- W1982184546 hasConcept C2777075537 @default.
- W1982184546 hasConcept C2777214474 @default.
- W1982184546 hasConcept C2777382497 @default.
- W1982184546 hasConcept C2780593183 @default.
- W1982184546 hasConcept C2780617729 @default.
- W1982184546 hasConcept C2908647359 @default.
- W1982184546 hasConcept C54355233 @default.
- W1982184546 hasConcept C55493867 @default.
- W1982184546 hasConcept C71924100 @default.
- W1982184546 hasConcept C86803240 @default.
- W1982184546 hasConcept C99454951 @default.
- W1982184546 hasConceptScore W1982184546C101762097 @default.
- W1982184546 hasConceptScore W1982184546C104317684 @default.
- W1982184546 hasConceptScore W1982184546C126322002 @default.
- W1982184546 hasConceptScore W1982184546C143065580 @default.
- W1982184546 hasConceptScore W1982184546C150194340 @default.
- W1982184546 hasConceptScore W1982184546C159047783 @default.
- W1982184546 hasConceptScore W1982184546C2522874641 @default.
- W1982184546 hasConceptScore W1982184546C2777075537 @default.
- W1982184546 hasConceptScore W1982184546C2777214474 @default.