FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982185635> ?p ?o ?g. }

• W1982185635 endingPage "124" @default.
• W1982185635 startingPage "113" @default.
• W1982185635 abstract "Genetic research on risk of alcohol, tobacco or drug dependence must make allowance for the partial overlap of risk-factors for initiation of use, and risk-factors for dependence or other outcomes in users. Except in the extreme cases where genetic and environmental risk-factors for initiation and dependence overlap completely or are uncorrelated, there is no consensus about how best to estimate the magnitude of genetic or environmental correlations between Initiation and Dependence in twin and family data. We explore by computer simulation the biases to estimates of genetic and environmental parameters caused by model misspecification when Initiation can only be defined as a binary variable. For plausible simulated parameter values, the two-stage genetic models that we consider yield estimates of genetic and environmental variances for Dependence that, although biased, are not very discrepant from the true values. However, estimates of genetic (or environmental) correlations between Initiation and Dependence may be seriously biased, and may differ markedly under different two-stage models. Such estimates may have little credibility unless external data favor selection of one particular model. These problems can be avoided if Initiation can be assessed as a multiple-category variable (e.g. never versus early-onset versus later onset user), with at least two categories measurable in users at risk for dependence. Under these conditions, under certain distributional assumptions, recovery of simulated genetic and environmental correlations becomes possible. Illustrative application of the model to Australian twin data on smoking confirmed substantial heritability of smoking persistence (42%) with minimal overlap with genetic influences on initiation." @default.
• W1982185635 created "2016-06-24" @default.
• W1982185635 creator A5010399208 @default.
• W1982185635 creator A5011336941 @default.
• W1982185635 creator A5012652688 @default.
• W1982185635 creator A5042130650 @default.
• W1982185635 creator A5076811441 @default.
• W1982185635 date "2002-04-01" @default.
• W1982185635 modified "2023-09-27" @default.
• W1982185635 title "Estimating Two-Stage Models for Genetic Influences on Alcohol, Tobacco or Drug Use Initiation and Dependence Vulnerability in Twin and Family Data" @default.
• W1982185635 cites W1514256295 @default.
• W1982185635 cites W1552608913 @default.
• W1982185635 cites W1561568624 @default.
• W1982185635 cites W2002964463 @default.
• W1982185635 cites W2009735362 @default.
• W1982185635 cites W2044758663 @default.
• W1982185635 cites W2047108558 @default.
• W1982185635 cites W2069860046 @default.
• W1982185635 cites W2080031511 @default.
• W1982185635 cites W2135718110 @default.
• W1982185635 cites W2142265247 @default.
• W1982185635 cites W2151891607 @default.
• W1982185635 cites W2155090722 @default.
• W1982185635 cites W2157750973 @default.
• W1982185635 cites W2162542540 @default.
• W1982185635 cites W2166913026 @default.
• W1982185635 doi "https://doi.org/10.1375/1369052022983" @default.
• W1982185635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11931689" @default.
• W1982185635 hasPublicationYear "2002" @default.
• W1982185635 type Work @default.
• W1982185635 sameAs 1982185635 @default.
• W1982185635 citedByCount "80" @default.
• W1982185635 countsByYear W19821856352012 @default.
• W1982185635 countsByYear W19821856352013 @default.
• W1982185635 countsByYear W19821856352014 @default.
• W1982185635 countsByYear W19821856352015 @default.
• W1982185635 countsByYear W19821856352016 @default.
• W1982185635 countsByYear W19821856352017 @default.
• W1982185635 countsByYear W19821856352018 @default.
• W1982185635 countsByYear W19821856352019 @default.
• W1982185635 countsByYear W19821856352021 @default.
• W1982185635 countsByYear W19821856352023 @default.
• W1982185635 crossrefType "journal-article" @default.
• W1982185635 hasAuthorship W1982185635A5010399208 @default.
• W1982185635 hasAuthorship W1982185635A5011336941 @default.
• W1982185635 hasAuthorship W1982185635A5012652688 @default.
• W1982185635 hasAuthorship W1982185635A5042130650 @default.
• W1982185635 hasAuthorship W1982185635A5076811441 @default.
• W1982185635 hasBestOaLocation W19821856351 @default.
• W1982185635 hasConcept C104317684 @default.
• W1982185635 hasConcept C105795698 @default.
• W1982185635 hasConcept C149782125 @default.
• W1982185635 hasConcept C154945302 @default.
• W1982185635 hasConcept C15744967 @default.
• W1982185635 hasConcept C161890455 @default.
• W1982185635 hasConcept C162324750 @default.
• W1982185635 hasConcept C169594400 @default.
• W1982185635 hasConcept C21547014 @default.
• W1982185635 hasConcept C2779268580 @default.
• W1982185635 hasConcept C2992519594 @default.
• W1982185635 hasConcept C33923547 @default.
• W1982185635 hasConcept C41008148 @default.
• W1982185635 hasConcept C54355233 @default.
• W1982185635 hasConcept C68873052 @default.
• W1982185635 hasConcept C70616004 @default.
• W1982185635 hasConcept C81917197 @default.
• W1982185635 hasConcept C86803240 @default.
• W1982185635 hasConceptScore W1982185635C104317684 @default.
• W1982185635 hasConceptScore W1982185635C105795698 @default.
• W1982185635 hasConceptScore W1982185635C149782125 @default.
• W1982185635 hasConceptScore W1982185635C154945302 @default.
• W1982185635 hasConceptScore W1982185635C15744967 @default.
• W1982185635 hasConceptScore W1982185635C161890455 @default.
• W1982185635 hasConceptScore W1982185635C162324750 @default.
• W1982185635 hasConceptScore W1982185635C169594400 @default.
• W1982185635 hasConceptScore W1982185635C21547014 @default.
• W1982185635 hasConceptScore W1982185635C2779268580 @default.
• W1982185635 hasConceptScore W1982185635C2992519594 @default.
• W1982185635 hasConceptScore W1982185635C33923547 @default.
• W1982185635 hasConceptScore W1982185635C41008148 @default.
• W1982185635 hasConceptScore W1982185635C54355233 @default.
• W1982185635 hasConceptScore W1982185635C68873052 @default.
• W1982185635 hasConceptScore W1982185635C70616004 @default.
• W1982185635 hasConceptScore W1982185635C81917197 @default.
• W1982185635 hasConceptScore W1982185635C86803240 @default.
• W1982185635 hasIssue "2" @default.
• W1982185635 hasLocation W19821856351 @default.
• W1982185635 hasLocation W19821856352 @default.
• W1982185635 hasOpenAccess W1982185635 @default.
• W1982185635 hasPrimaryLocation W19821856351 @default.
• W1982185635 hasRelatedWork W1982157329 @default.
• W1982185635 hasRelatedWork W2018278481 @default.
• W1982185635 hasRelatedWork W2034300459 @default.
• W1982185635 hasRelatedWork W2041056396 @default.
• W1982185635 hasRelatedWork W2321964254 @default.
• W1982185635 hasRelatedWork W2324748999 @default.
• W1982185635 hasRelatedWork W2767439522 @default.
• W1982185635 hasRelatedWork W2949403358 @default.

• next