FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982193071> ?p ?o ?g. }

• W1982193071 endingPage "e7511" @default.
• W1982193071 startingPage "e7511" @default.
• W1982193071 abstract "Background and Aims microRNAs (miRNAs) are small noncoding RNAs that regulate cognate mRNAs post-transcriptionally. miRNAs have been implicated in regulating gene expression in embryonic developmental processes, including proliferation and differentiation. The liver is a multifunctional organ, which undergoes rapid changes during the developmental period and relies on tightly-regulated gene expression. Little is known regarding the complex expression patterns of both mRNAs and miRNAs during the early stages of human liver development, and the role of miRNAs in the regulation of this process has not been studied. The aim of this work was to study the impact of miRNAs on gene expression during early human liver development. Methods Global gene and miRNA expression were profiled in adult and in 9–12w human embryonic livers, using high-density microarrays and quantitative RT-PCR. Results Embryonic liver samples exhibited a gene expression profile that differentiated upon progression in the developmental process, and revealed multiple regulated genes. miRNA expression profiling revealed four major expression patterns that correlated with the known function of regulated miRNAs. Comparison of the expression of the most regulated miRNAs to that of their putative targets using a novel algorithm revealed a significant anti-correlation for several miRNAs, and identified the most active miRNAs in embryonic and in adult liver. Furthermore, our algorithm facilitated the identification of TGFβ-R1 as a novel target gene of let-7. Conclusions Our results uncover multiple regulated miRNAs and genes throughout human liver development, and our algorithm assists in identification of novel miRNA targets with potential roles in liver development." @default.
• W1982193071 created "2016-06-24" @default.
• W1982193071 creator A5023898049 @default.
• W1982193071 creator A5026115410 @default.
• W1982193071 creator A5035365163 @default.
• W1982193071 creator A5040126994 @default.
• W1982193071 creator A5044109037 @default.
• W1982193071 creator A5046152936 @default.
• W1982193071 creator A5049768093 @default.
• W1982193071 creator A5050861576 @default.
• W1982193071 creator A5056779273 @default.
• W1982193071 creator A5058749953 @default.
• W1982193071 creator A5066229845 @default.
• W1982193071 creator A5071992679 @default.
• W1982193071 creator A5090206769 @default.
• W1982193071 date "2009-10-20" @default.
• W1982193071 modified "2023-10-12" @default.
• W1982193071 title "Comprehensive Gene and microRNA Expression Profiling Reveals a Role for microRNAs in Human Liver Development" @default.
• W1982193071 cites W1949977953 @default.
• W1982193071 cites W1963717607 @default.
• W1982193071 cites W1965306643 @default.
• W1982193071 cites W1973614663 @default.
• W1982193071 cites W1978337436 @default.
• W1982193071 cites W198220950 @default.
• W1982193071 cites W1988163167 @default.
• W1982193071 cites W1989590372 @default.
• W1982193071 cites W1990868443 @default.
• W1982193071 cites W1997424007 @default.
• W1982193071 cites W2011821756 @default.
• W1982193071 cites W2015858554 @default.
• W1982193071 cites W2017617041 @default.
• W1982193071 cites W2020541351 @default.
• W1982193071 cites W2031515432 @default.
• W1982193071 cites W2033048926 @default.
• W1982193071 cites W2038696333 @default.
• W1982193071 cites W2040851473 @default.
• W1982193071 cites W2050869737 @default.
• W1982193071 cites W2059073003 @default.
• W1982193071 cites W2065566217 @default.
• W1982193071 cites W2076000793 @default.
• W1982193071 cites W2083381199 @default.
• W1982193071 cites W2083917663 @default.
• W1982193071 cites W2091511052 @default.
• W1982193071 cites W2094340038 @default.
• W1982193071 cites W2098425296 @default.
• W1982193071 cites W2117391818 @default.
• W1982193071 cites W2125818518 @default.
• W1982193071 cites W2146046635 @default.
• W1982193071 cites W2149146453 @default.
• W1982193071 cites W2149880040 @default.
• W1982193071 cites W2151602225 @default.
• W1982193071 cites W2153562609 @default.
• W1982193071 cites W2156949967 @default.
• W1982193071 cites W2159686118 @default.
• W1982193071 cites W2159767268 @default.
• W1982193071 cites W2160697532 @default.
• W1982193071 cites W2163986503 @default.
• W1982193071 cites W2167639861 @default.
• W1982193071 cites W2168783124 @default.
• W1982193071 cites W2170647698 @default.
• W1982193071 cites W2171697766 @default.
• W1982193071 doi "https://doi.org/10.1371/journal.pone.0007511" @default.
• W1982193071 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2760133" @default.
• W1982193071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19841744" @default.
• W1982193071 hasPublicationYear "2009" @default.
• W1982193071 type Work @default.
• W1982193071 sameAs 1982193071 @default.
• W1982193071 citedByCount "109" @default.
• W1982193071 countsByYear W19821930712012 @default.
• W1982193071 countsByYear W19821930712013 @default.
• W1982193071 countsByYear W19821930712014 @default.
• W1982193071 countsByYear W19821930712015 @default.
• W1982193071 countsByYear W19821930712016 @default.
• W1982193071 countsByYear W19821930712017 @default.
• W1982193071 countsByYear W19821930712018 @default.
• W1982193071 countsByYear W19821930712019 @default.
• W1982193071 countsByYear W19821930712020 @default.
• W1982193071 countsByYear W19821930712021 @default.
• W1982193071 countsByYear W19821930712022 @default.
• W1982193071 countsByYear W19821930712023 @default.
• W1982193071 crossrefType "journal-article" @default.
• W1982193071 hasAuthorship W1982193071A5023898049 @default.
• W1982193071 hasAuthorship W1982193071A5026115410 @default.
• W1982193071 hasAuthorship W1982193071A5035365163 @default.
• W1982193071 hasAuthorship W1982193071A5040126994 @default.
• W1982193071 hasAuthorship W1982193071A5044109037 @default.
• W1982193071 hasAuthorship W1982193071A5046152936 @default.
• W1982193071 hasAuthorship W1982193071A5049768093 @default.
• W1982193071 hasAuthorship W1982193071A5050861576 @default.
• W1982193071 hasAuthorship W1982193071A5056779273 @default.
• W1982193071 hasAuthorship W1982193071A5058749953 @default.
• W1982193071 hasAuthorship W1982193071A5066229845 @default.
• W1982193071 hasAuthorship W1982193071A5071992679 @default.
• W1982193071 hasAuthorship W1982193071A5090206769 @default.
• W1982193071 hasBestOaLocation W19821930711 @default.
• W1982193071 hasConcept C104317684 @default.
• W1982193071 hasConcept C145059251 @default.
• W1982193071 hasConcept C145103041 @default.

• next