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- W1982196732 abstract "It has been found that ultrasound has a unique effect on arterial and venous dilation as well as tissue perfusion. Our group found that low frequency ultrasound (20 kHz, 0.1 w/cm2) results in coronary arterial and coronary venous dilation in dogs. The magnitude of vasodilation is similar to that seen with nitroglycerine (NTG) administration but unlike NTG, USD does not lower blood pressure. Our human studies show that USD induces brachial arterial dilation after 1 min with the vasodilatory effect lasting 20 min. In animals we ligated coronary arteries, stopping epicardial coronary flow, resulting in a drop in myocardial tissue perfusion to 70% of normal; myocardial tissue pH fell from 7.43 to 7.05. After 60 min of USD, tissue perfusion improved by 20% and pH normalized in spite of persistent coronary artery occlusion. The enhanced perfusion effect of ultrasound was eliminated if an inhibitor of nitric oxide synthase was given prior to ultrasound exposure. Conclusions: low frequency ultrasound causes vasodilation and improves tissue perfusion. These effects appear to be mediated at least in part by the USD enhancing tissue release of nitric oxide." @default.
- W1982196732 created "2016-06-24" @default.
- W1982196732 creator A5040204150 @default.
- W1982196732 date "2011-10-01" @default.
- W1982196732 modified "2023-09-26" @default.
- W1982196732 title "Low frequency therapeutic ultrasound causes vasodilation and enhanced tissue perfusion" @default.
- W1982196732 doi "https://doi.org/10.1121/1.3654960" @default.
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