FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982196927> ?p ?o ?g. }

• W1982196927 endingPage "525" @default.
• W1982196927 startingPage "521" @default.
• W1982196927 abstract "Transforming growth factor-β 1 (TGF-β 1 ) has been shown to be an injury-related peptide growth factor within the mammalian central nervous system. We tested whether TGF-β 1 has the capacity to protect rat neocortical neurons against excitotoxic damage in vitro and mouse neocortex against ischemic injury in vivo. After 14 days in vitro, cultured neurons from rat cerebral cortex were exposed to 1 m M l-glutamate in serum-free culture medium. The cultures received TGF-β 1 immediately after the addition of glutamate. Eighteen hours later, the cell viability of the cultures was determined using trypan blue exclusion. TGF-β 1 (1–10 ng/ml) significantly reduced the excitotoxic neuronal damage in a concentration-dependent manner. In vivo, male NMRI mice were subjected to a permanent occlusion of the left middle cerebral artery by microbipolar electrocoagulation. After 48 h, the animals received a transcardiac injection of carbon black. The area of ischemia (devoid of carbon) was restricted to the neocortex and its size was determined planimetrically by means of an image-analyzing system. The treatment with TGF-β 1 (1 μg/kg i.c.v.) at 6, 4, or 2 h prior to vessel occlusion reduced the area of ischemia by 5.3, 10.0, and 9.6%, respectively. The effect of the treatment with TGF-β 1 was statistically significant (p < 0.05 by two-way ANOVA). The present in vitro and in vivo data suggest that TGF-β 1 has the capacity to diminish the deleterious consequences of an excitotoxic or ischemic insult." @default.
• W1982196927 created "2016-06-24" @default.
• W1982196927 creator A5011007885 @default.
• W1982196927 creator A5028603581 @default.
• W1982196927 creator A5066581807 @default.
• W1982196927 date "1993-05-01" @default.
• W1982196927 modified "2023-09-28" @default.
• W1982196927 title "Transforming Growth Factor-β₁Prevents Glutamate Neurotoxicity in Rat Neocortical Cultures and Protects Mouse Neocortex from Ischemic Injury in vivo" @default.
• W1982196927 cites W1500403088 @default.
• W1982196927 cites W1515063177 @default.
• W1982196927 cites W1595132023 @default.
• W1982196927 cites W1965586307 @default.
• W1982196927 cites W1980035932 @default.
• W1982196927 cites W1980920786 @default.
• W1982196927 cites W1984511547 @default.
• W1982196927 cites W2016575029 @default.
• W1982196927 cites W2016980602 @default.
• W1982196927 cites W2019759081 @default.
• W1982196927 cites W2020333978 @default.
• W1982196927 cites W2026394731 @default.
• W1982196927 cites W2038901751 @default.
• W1982196927 cites W2043725292 @default.
• W1982196927 cites W2046511312 @default.
• W1982196927 cites W2058926489 @default.
• W1982196927 cites W2073402264 @default.
• W1982196927 cites W2088017195 @default.
• W1982196927 cites W2106829291 @default.
• W1982196927 cites W2346002398 @default.
• W1982196927 cites W4211166816 @default.
• W1982196927 doi "https://doi.org/10.1038/jcbfm.1993.67" @default.
• W1982196927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8097519" @default.
• W1982196927 hasPublicationYear "1993" @default.
• W1982196927 type Work @default.
• W1982196927 sameAs 1982196927 @default.
• W1982196927 citedByCount "221" @default.
• W1982196927 countsByYear W19821969272012 @default.
• W1982196927 countsByYear W19821969272013 @default.
• W1982196927 countsByYear W19821969272014 @default.
• W1982196927 countsByYear W19821969272015 @default.
• W1982196927 countsByYear W19821969272016 @default.
• W1982196927 countsByYear W19821969272017 @default.
• W1982196927 countsByYear W19821969272018 @default.
• W1982196927 countsByYear W19821969272019 @default.
• W1982196927 countsByYear W19821969272020 @default.
• W1982196927 countsByYear W19821969272021 @default.
• W1982196927 countsByYear W19821969272023 @default.
• W1982196927 crossrefType "journal-article" @default.
• W1982196927 hasAuthorship W1982196927A5011007885 @default.
• W1982196927 hasAuthorship W1982196927A5028603581 @default.
• W1982196927 hasAuthorship W1982196927A5066581807 @default.
• W1982196927 hasConcept C118131993 @default.
• W1982196927 hasConcept C126322002 @default.
• W1982196927 hasConcept C134018914 @default.
• W1982196927 hasConcept C150903083 @default.
• W1982196927 hasConcept C169760540 @default.
• W1982196927 hasConcept C170493617 @default.
• W1982196927 hasConcept C202751555 @default.
• W1982196927 hasConcept C207001950 @default.
• W1982196927 hasConcept C25498285 @default.
• W1982196927 hasConcept C2777222312 @default.
• W1982196927 hasConcept C2779491297 @default.
• W1982196927 hasConcept C2780070996 @default.
• W1982196927 hasConcept C29730261 @default.
• W1982196927 hasConcept C42219234 @default.
• W1982196927 hasConcept C541997718 @default.
• W1982196927 hasConcept C55493867 @default.
• W1982196927 hasConcept C61174792 @default.
• W1982196927 hasConcept C71924100 @default.
• W1982196927 hasConcept C86803240 @default.
• W1982196927 hasConcept C98274493 @default.
• W1982196927 hasConceptScore W1982196927C118131993 @default.
• W1982196927 hasConceptScore W1982196927C126322002 @default.
• W1982196927 hasConceptScore W1982196927C134018914 @default.
• W1982196927 hasConceptScore W1982196927C150903083 @default.
• W1982196927 hasConceptScore W1982196927C169760540 @default.
• W1982196927 hasConceptScore W1982196927C170493617 @default.
• W1982196927 hasConceptScore W1982196927C202751555 @default.
• W1982196927 hasConceptScore W1982196927C207001950 @default.
• W1982196927 hasConceptScore W1982196927C25498285 @default.
• W1982196927 hasConceptScore W1982196927C2777222312 @default.
• W1982196927 hasConceptScore W1982196927C2779491297 @default.
• W1982196927 hasConceptScore W1982196927C2780070996 @default.
• W1982196927 hasConceptScore W1982196927C29730261 @default.
• W1982196927 hasConceptScore W1982196927C42219234 @default.
• W1982196927 hasConceptScore W1982196927C541997718 @default.
• W1982196927 hasConceptScore W1982196927C55493867 @default.
• W1982196927 hasConceptScore W1982196927C61174792 @default.
• W1982196927 hasConceptScore W1982196927C71924100 @default.
• W1982196927 hasConceptScore W1982196927C86803240 @default.
• W1982196927 hasConceptScore W1982196927C98274493 @default.
• W1982196927 hasIssue "3" @default.
• W1982196927 hasLocation W19821969271 @default.
• W1982196927 hasLocation W19821969272 @default.
• W1982196927 hasOpenAccess W1982196927 @default.
• W1982196927 hasPrimaryLocation W19821969271 @default.
• W1982196927 hasRelatedWork W2064786341 @default.
• W1982196927 hasRelatedWork W2071070793 @default.
• W1982196927 hasRelatedWork W2090361924 @default.

• next