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- W1982198737 abstract "To the Editor. —Jacobs et al 1 report the first apparent case, to my knowledge, of a failure of ceftriaxone to sterilize cerebrospinal fluid (CSF) after three days of therapy in a child with Haemophilus influenzae type b pneumonia with sepsis. This information stands in contrast to a large body of clinical data in which ceftriaxone has been used to treat meningitis and invasive soft tissue disease. 2-8 The report is of great concern to me and, I believe, to others who use ceftriaxone and other third-generation cephalosporins preferentially as empirical therapy for meningitis. 9 Several aspects of this case report deserve comment. Assuming that the organisms cultured from the blood and CSF were identical isolates, the minimal inhibitory concentration of H influenzae type b to ceftriaxone of these strains appears to be identical to previously reported values. 10 Unfortunately, a minimum bactericidal concentration was not reported. It is possible" @default.
- W1982198737 created "2016-06-24" @default.
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- W1982198737 date "1988-05-20" @default.
- W1982198737 modified "2023-10-18" @default.
- W1982198737 title "Ceftriaxone in Haemophilus influenzae Type b Meningitis" @default.
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- W1982198737 doi "https://doi.org/10.1001/jama.1988.03720190023023" @default.
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