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- W1982201645 abstract "THE neuroendocrine and the immune systems are interconnected. Monoclonal antibodies against major histocompatibility complex (MHC) class I, class II, CD4, CD8, pan T cells, and macrophages were used for immunostaining brains from adrenalectomized (ADX) and shamoperated rats to investigate the potential involvement of the immune/inflammatory mechanisms in the neurodegeneration of hippocampus after ADX. Our results demonstrate upregulation of MHC class II, CD4 antigens and activated microglial marker-ED1 expression selectively in the hippocampus after ADX. The absence of CD5 reactivity precludes that these activated cells were T lymphocytes. The activated microglial cells may either be instrumental in the hippocampal neuronal loss or activated secondarily to the neuronal degeneration after long-term adrenalectomy." @default.
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- W1982201645 date "1997-03-01" @default.
- W1982201645 modified "2023-10-16" @default.
- W1982201645 title "Expression of MHC class II, CD4+ and ED1 molecules in association with selective hippocampal neuronal degeneration after long-term adrenalectomy" @default.
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- W1982201645 doi "https://doi.org/10.1097/00001756-199703030-00033" @default.
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