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- W1982202968 abstract "Left ventricular hypertrophy (LVH) is a major cardiac sequel of hypertension and a powerful predictor of cardiovascular morbidity and mortality. Several nonpopulation-based studies explored the association between insulin-like growth factor-1 (IGF-I) and LVH with conflicting results. The aim of the present study was to investigate the association of serum IGF-I or IGF-binding protein-3 (IGFBP-3) levels with LVH in a population-based study.From the cross-sectional Study of Health in Pomerania, 1865 participants aged 45-79 years were included. Echocardiography was performed and left ventricular mass index calculated. LVH was defined as left ventricular mass index more than 48 g/m for men and more than 44 g/m for women. Serum IGF-I and IGFBP-3 levels were determined by chemiluminescence immunoassays. Analysis of variance and logistic regression were performed.LVH was present in 52.0% of the women and 50.8% of the men. Our data did not obtain any significant association between serum IGF-I levels and left ventricular mass index or LVH in both men and women. Regarding IGFBP-3, women with low IGFBP-3 levels had an almost two-fold higher odds of LVH [odds ratio 1.76 (95% confidence limit 1.04-2.95)] compared with women with moderate IGFBP-3 levels. No such relation became apparent in men.No association between IGF-I levels and LVH was found. Potential hypertrophic effects of free serum IGF-I levels might be mediated by lower IGFBP-3 levels." @default.
- W1982202968 created "2016-06-24" @default.
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- W1982202968 date "2010-04-01" @default.
- W1982202968 modified "2023-10-16" @default.
- W1982202968 title "Lack of association between insulin-like growth factor-1 or insulin-like growth factor-binding protein-3 and left ventricular hypertrophy: results of the Study of Health in Pomerania" @default.
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- W1982202968 doi "https://doi.org/10.1097/hjh.0b013e328336274a" @default.
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