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- W1982202988 abstract "Rhabdomyosarcoma (RMS) is the most common type of soft tissue sarcoma in children. Regarding histopathological criteria, RMS can be divided into 2 main subtypes: embryonal and alveolar. These subtypes differ considerably in their clinical phenotype and molecular features. Abnormal regulation or mutation of signalling pathways that regulate normal embryonic development such as Notch, Hedgehog, and Wnt is a recurrent feature in tumorigenesis. Herein, the general features of each of the three pathways, their implication in cancer and particularly in RMS are reviewed. Finally, the cross-talking among these three pathways and the possibility of better understanding of the horizontal communication among them, leading to the development of more potent therapeutic approaches, are discussed." @default.
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- W1982202988 date "2012-01-01" @default.
- W1982202988 modified "2023-10-10" @default.
- W1982202988 title "<i>Notch, Wnt,</i>and<i>Hedgehog</i>Pathways in Rhabdomyosarcoma: From Single Pathways to an Integrated Network" @default.
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- W1982202988 doi "https://doi.org/10.1155/2012/695603" @default.
- W1982202988 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3329671" @default.
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