Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982203224> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W1982203224 endingPage "12" @default.
- W1982203224 startingPage "1" @default.
- W1982203224 abstract "In two groups of epileptic children receiving carbamazepine (CBZ) therapy with or without valproic acid (VPA) comedication, we investigate the drug interactions of VPA on serum CBZ and its metabolites' concentrations, concentration ratios, and level/dose ratios. Serum total and free CBZ-10, 11-epoxide (CBZ-E) concentrations are significantly increased in patients taking CBZ plus VPA, together with higher CBZ-E/CBZ concentration ratios and CBZ-E level/dose ratios. These results reflect the accumulation of CBZ-E. The decreased concentration ratios of trans-10, 11-dihydroxy-10, 11-dihydro-CBZ (CBZ-H)/CBZ-E observed in patients taking CBZ plus VPA suggest an inhibition in the biotransformation from CBZ-E to CBZ-H. Significant negative correlations are found between serum VPA level and CBZ-H/CBZ-E concentration ratios, indicating that the inhibition of CBZ-E hydrolysis by VPA may depend on the concentration of VPA (total or free CBZ-H/CBZ-E concentration ratio = [formula: see text], respectively). VPA concentration also shows significant positive correlations with CBZ-E and CBZ level/dose ratios. Patients taking CBZ plus VPA have significant higher free fractions of CBZ and CBZ-E than do patients on CBZ alone, suggesting a protein-binding displacement by VPA." @default.
- W1982203224 created "2016-06-24" @default.
- W1982203224 creator A5004227153 @default.
- W1982203224 creator A5015624405 @default.
- W1982203224 creator A5051751421 @default.
- W1982203224 date "1995-02-01" @default.
- W1982203224 modified "2023-09-23" @default.
- W1982203224 title "Interactions of Valproic Acid with Carbamazepine and its Metabolitesʼ Concentrations, Concentration Ratios, and Level/Dose Ratios in Epileptic Children" @default.
- W1982203224 doi "https://doi.org/10.1097/00002826-199502000-00001" @default.
- W1982203224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8665529" @default.
- W1982203224 hasPublicationYear "1995" @default.
- W1982203224 type Work @default.
- W1982203224 sameAs 1982203224 @default.
- W1982203224 citedByCount "17" @default.
- W1982203224 countsByYear W19822032242013 @default.
- W1982203224 countsByYear W19822032242020 @default.
- W1982203224 countsByYear W19822032242021 @default.
- W1982203224 crossrefType "journal-article" @default.
- W1982203224 hasAuthorship W1982203224A5004227153 @default.
- W1982203224 hasAuthorship W1982203224A5015624405 @default.
- W1982203224 hasAuthorship W1982203224A5051751421 @default.
- W1982203224 hasConcept C118552586 @default.
- W1982203224 hasConcept C126322002 @default.
- W1982203224 hasConcept C185592680 @default.
- W1982203224 hasConcept C2775858608 @default.
- W1982203224 hasConcept C2777172819 @default.
- W1982203224 hasConcept C2778186239 @default.
- W1982203224 hasConcept C2778337148 @default.
- W1982203224 hasConcept C2779253243 @default.
- W1982203224 hasConcept C3020081911 @default.
- W1982203224 hasConcept C71924100 @default.
- W1982203224 hasConcept C98274493 @default.
- W1982203224 hasConceptScore W1982203224C118552586 @default.
- W1982203224 hasConceptScore W1982203224C126322002 @default.
- W1982203224 hasConceptScore W1982203224C185592680 @default.
- W1982203224 hasConceptScore W1982203224C2775858608 @default.
- W1982203224 hasConceptScore W1982203224C2777172819 @default.
- W1982203224 hasConceptScore W1982203224C2778186239 @default.
- W1982203224 hasConceptScore W1982203224C2778337148 @default.
- W1982203224 hasConceptScore W1982203224C2779253243 @default.
- W1982203224 hasConceptScore W1982203224C3020081911 @default.
- W1982203224 hasConceptScore W1982203224C71924100 @default.
- W1982203224 hasConceptScore W1982203224C98274493 @default.
- W1982203224 hasIssue "1" @default.
- W1982203224 hasLocation W19822032241 @default.
- W1982203224 hasLocation W19822032242 @default.
- W1982203224 hasOpenAccess W1982203224 @default.
- W1982203224 hasPrimaryLocation W19822032241 @default.
- W1982203224 hasRelatedWork W1973147526 @default.
- W1982203224 hasRelatedWork W1993760950 @default.
- W1982203224 hasRelatedWork W2025375708 @default.
- W1982203224 hasRelatedWork W2027333142 @default.
- W1982203224 hasRelatedWork W2074714060 @default.
- W1982203224 hasRelatedWork W2150760847 @default.
- W1982203224 hasRelatedWork W2396026399 @default.
- W1982203224 hasRelatedWork W2613541259 @default.
- W1982203224 hasRelatedWork W2906906539 @default.
- W1982203224 hasRelatedWork W50701402 @default.
- W1982203224 hasVolume "18" @default.
- W1982203224 isParatext "false" @default.
- W1982203224 isRetracted "false" @default.
- W1982203224 magId "1982203224" @default.
- W1982203224 workType "article" @default.