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- W1982204565 abstract "ABSTRACT Naturally acquired antibodies to Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP-1), the variant surface antigens expressed on the surface of infected erythrocytes, are thought to play a role in protection against P. falciparum malaria. Here, we have studied the development of antibodies to PfEMP-1 in adult malaria patients living in Rourkela, India, an area with a low malaria transmission rate, and prevalence of antibodies to PfEMP-1 in residents of San Dulakudar, India, a village in which P. falciparum malaria is hyperendemic. Convalescent-phase sera from adult malaria patients from Rourkela agglutinate homologous P. falciparum isolates as well as some heterologous isolates, suggesting that they develop partially cross-reactive antibodies to PfEMP-1 following infection. Adult sera from San Dulakudar agglutinate diverse P. falciparum isolates, suggesting that they have antibodies with wide recognition of diverse PfEMP-1. Mixed-agglutination assays using pairs of P. falciparum isolates confirm the presence of both variant-specific and partially cross-reactive antibodies in convalescent-phase sera from Rourkela and adult sera from San Dulakudar. Analysis of PfEMP-1 sequences suggests a molecular basis for the observed cross-reactivity." @default.
- W1982204565 created "2016-06-24" @default.
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- W1982204565 date "2003-02-01" @default.
- W1982204565 modified "2023-10-16" @default.
- W1982204565 title "<i>Plasmodium falciparum</i> Infection Elicits Both Variant-Specific and Cross-Reactive Antibodies against Variant Surface Antigens" @default.
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- W1982204565 doi "https://doi.org/10.1128/iai.71.2.597-604.2003" @default.
- W1982204565 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/145347" @default.
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