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• W1982207704 endingPage "2973" @default.
• W1982207704 startingPage "2969" @default.
• W1982207704 abstract "By affinity chromatography on heparin-Sepharose, two classes of lipoproteins were separated from high density lipoproteins (HDL) isolated from patients with primary or secondary lecithin:cholesterol acyltransferase (LCATase; EC 2.3.1.43) deficiency and from normal subjects. The unretained fraction, HDL A , was characterized by having apoA-I as a major apoprotein; it also contained apoA-II, -C-II, and -C-III but it contained only traces of immunodetectable apoE and no apoB. The retained fraction, HDL E , had apoE as the major apoprotein; it also contained apoA-I, -A-II, -B, -C-II, and -C-III. The relative concentration of apoA-I increased with increasing density in the HDL E subclass. Compared to HDL A , HDL E had a significantly higher cholesterol content and a lower protein concentration. HDL E was mainly (90%) contained within the HDL 2 subfraction. Contamination of HDL E by low density lipoproteins (LDL) or Lp(a) was minimal on the basis of pre-β-electrophoretic mobility and absence of albumin, respectively. Contamination by LDL or Lp(a) could be resolved in part by application of HDL E to concanavalin A-Sepharose or to heparin-Sepharose with a shallow gradient. When evaluated as substrates for a highly purified LCATase preparation, the initial reaction rates and V max obtained with HDL A were always higher than those obtained with HDL E in any given plasma. However, both HDL subclasses from LCATase-deficient subjects were better substrates than the corresponding HDL subclasses from normal plasma. Also, both HDL 3A and HDL 3E isolated from normal HDL 3 were better substrates than the corresponding subclasses isolated from normal HDL 2 . The recognition of this compositional and functional heterogeneity within HDL will allow a better understanding of the metabolism of this lipoprotein class." @default.
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• W1982207704 date "1980-05-01" @default.
• W1982207704 modified "2023-10-16" @default.
• W1982207704 title "Heterogeneity of human high density lipoprotein: Presence of lipoproteins with and without apoE and their roles as substrates for lecithin:cholesterol acyltransferase reaction" @default.
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• W1982207704 doi "https://doi.org/10.1073/pnas.77.5.2969" @default.
• W1982207704 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/349528" @default.
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• W1982207704 hasPublicationYear "1980" @default.
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