FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982207778> ?p ?o ?g. }

• W1982207778 endingPage "A53" @default.
• W1982207778 startingPage "A53" @default.
• W1982207778 abstract "<h3>Background</h3> Cardiac resynchronisation therapy (CRT) is an established treatment for patients with advanced heart failure (HF). However, a proportion of patients do not derive benefit post implantation of CRT. Despite an established predictive role in HF, the significance of RV dysfunction in gauging clinical benefit from CRT has not been investigated. Cardiovascular magnetic resonance (CMR) is an important tool in the assessment of HF and is considered the gold-standard in estimating RV function. We used this technique to assess the impact of RV dysfunction on clinical outcomes following CRT implantation. <h3>Methods</h3> We evaluated 48 consecutive patients attending a heart failure pacing clinic who had a CMR study within 6 months prior to CRT implantation. Clinical, biochemical, ECG and imaging data were collected. Biventricular function and myocardial scar were assessed by CMR including gadolinium enhancement. The primary end-point was a composite of all cause mortality (ACM) or unplanned cardiovascular hospitalisation. <h3>Results</h3> The mean age was 64.5±12.7 years. HF was ischaemic in 42% of patients, and 85% were in NYHA class III/IV at the time of implantation. Atrial fibrillation/flutter was found in 27% of patients. The mean LVEF estimated by CMR was 27±8%, while the median RVEF was 52% (IQR 35%–63%). The mean tricuspid annular plane systolic excursion (TAPSE) was 14.0±6.0 mm, and the mean pulmonary artery pressure (on echocardiography) was 37 ±10 mm Hg. Ten patients (21%) met the primary end-point over a mean follow-up of 28.6 months. On time-to-event analysis, only atrial fibrillation (HR 4.8, p=0.02) and RV dysfunction, ie, reduced RVEF (HR 0.96 per 1% EF, p=0.01) or TAPSE (HR 0.80 per mm, p<0.01) were independent predictors of the primary end-point. Atrial fibrillation and low RVEF were the only independent predictors of mortality (p=0.03 and 0.04, respectively). <h3>Conclusions</h3> RV dysfunction is an independent predictor of adverse clinical outcomes following CRT. The assessment of RV function may be considered in patient selection for CRT implantation." @default.
• W1982207778 created "2016-06-24" @default.
• W1982207778 creator A5024868871 @default.
• W1982207778 creator A5028116777 @default.
• W1982207778 creator A5038622452 @default.
• W1982207778 creator A5048962022 @default.
• W1982207778 creator A5064634320 @default.
• W1982207778 creator A5088713964 @default.
• W1982207778 date "2011-06-01" @default.
• W1982207778 modified "2023-10-16" @default.
• W1982207778 title "91 Right ventricular dysfunction identifies clinical outcomes following cardiac resynchronisation therapy" @default.
• W1982207778 doi "https://doi.org/10.1136/heartjnl-2011-300198.91" @default.
• W1982207778 hasPublicationYear "2011" @default.
• W1982207778 type Work @default.
• W1982207778 sameAs 1982207778 @default.
• W1982207778 citedByCount "0" @default.
• W1982207778 crossrefType "journal-article" @default.
• W1982207778 hasAuthorship W1982207778A5024868871 @default.
• W1982207778 hasAuthorship W1982207778A5028116777 @default.
• W1982207778 hasAuthorship W1982207778A5038622452 @default.
• W1982207778 hasAuthorship W1982207778A5048962022 @default.
• W1982207778 hasAuthorship W1982207778A5064634320 @default.
• W1982207778 hasAuthorship W1982207778A5088713964 @default.
• W1982207778 hasBestOaLocation W19822077781 @default.
• W1982207778 hasConcept C126322002 @default.
• W1982207778 hasConcept C164705383 @default.
• W1982207778 hasConcept C2778198053 @default.
• W1982207778 hasConcept C2778292772 @default.
• W1982207778 hasConcept C2779161974 @default.
• W1982207778 hasConcept C71924100 @default.
• W1982207778 hasConcept C78085059 @default.
• W1982207778 hasConceptScore W1982207778C126322002 @default.
• W1982207778 hasConceptScore W1982207778C164705383 @default.
• W1982207778 hasConceptScore W1982207778C2778198053 @default.
• W1982207778 hasConceptScore W1982207778C2778292772 @default.
• W1982207778 hasConceptScore W1982207778C2779161974 @default.
• W1982207778 hasConceptScore W1982207778C71924100 @default.
• W1982207778 hasConceptScore W1982207778C78085059 @default.
• W1982207778 hasIssue "Suppl 1" @default.
• W1982207778 hasLocation W19822077781 @default.
• W1982207778 hasOpenAccess W1982207778 @default.
• W1982207778 hasPrimaryLocation W19822077781 @default.
• W1982207778 hasRelatedWork W2051712573 @default.
• W1982207778 hasRelatedWork W2077083067 @default.
• W1982207778 hasRelatedWork W2091139515 @default.
• W1982207778 hasRelatedWork W2355594703 @default.
• W1982207778 hasRelatedWork W2361407492 @default.
• W1982207778 hasRelatedWork W2538662566 @default.
• W1982207778 hasRelatedWork W3029306217 @default.
• W1982207778 hasRelatedWork W3033076790 @default.
• W1982207778 hasRelatedWork W4206264227 @default.
• W1982207778 hasRelatedWork W4382048704 @default.
• W1982207778 hasVolume "97" @default.
• W1982207778 isParatext "false" @default.
• W1982207778 isRetracted "false" @default.
• W1982207778 magId "1982207778" @default.
• W1982207778 workType "article" @default.