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- W1982209533 abstract "Abstract Administration of sublethal amounts of actinomycin D, α-amanitin, cycloheximide and lead acetate to mice enhances the sensitivity to endotoxin 80- to 350-fold, as judged by the decrease in the LD 50 , whereas cyclophosphamide, methotrexate, 5-fluorouracil and azathioprine fail to enhance sensitivity. Pre-treatment of mice with actinomycin D or cycloheximide, and simultaneous administration of lead acetate does not markedly alter the clearance of a small but toxic dose (12·5 μg) of Cr 51 -labelled endotoxin from the circulation 60 min after endotoxin injection. These substances however, decrease the clearance rate of a colloidal carbon suspension. It is concluded that inhibition of RNA and protein synthesis is responsible for the sensitizing effect and that this inhibition is not operative through a decreased clearance of endotoxin, although the phagocytic capacity is impaired. A decreased synthesis of detoxifying enzymes may be the prime target of inhibitors of RNA and protein synthesis responsible for the events leading to increased sensitivity." @default.
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- W1982209533 date "1972-08-01" @default.
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- W1982209533 title "Toxicity, clearance and distribution of endotoxin in mice as influenced by actinomycin D, cycloheximide, α-amanitin and lead acetate" @default.
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- W1982209533 doi "https://doi.org/10.1016/0041-0101(72)90175-4" @default.
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