FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982210884> ?p ?o ?g. }

• W1982210884 endingPage "963" @default.
• W1982210884 startingPage "954" @default.
• W1982210884 abstract "Minimally modified low-density lipoprotein (mm-LDL) induces intimal foam cell formation, which is promoted by endoplasmic reticulum stress (ERS), a cross-point to link cellular processes with multiple risk factors that exist in all stages of atherosclerosis. However, it remains unclear whether mm-LDL-induced lipid accumulation in macrophages involves ERS and its underlying mechanisms. We showed that mm-LDL induced the accumulation of lipid droplets in RAW264.7 macrophages with increased free cholesterol in the endoplasmic reticulum, which was markedly attenuated by pretreatment with an antibody against toll-like receptor 4 (TLR4). Additionally, mm-LDL stimulated the transport of Cy3-labeled activating transcription factor 6 (ATF6), a key sensor to the unfolded protein response (UPR), from cytoplasm into nucleus. The expression of phosphorylated inositol-requiring enzyme 1 (p-IRE1), another sensor to the UPR, and its two downstream molecules, X box binding protein 1 and glucose-regulated protein 78 (GRP78), were significantly upregulated by mm-LDL. The alterations induced by mm-LDL were all significantly inhibited by antibodies against TLR4 or CD36. In addition, the upregulation of p-IRE1 and GRP78 and the nuclear translocation of ATF6 induced by mm-LDL were significantly attenuated by TLR4 siRNA. These results suggest that mm-LDL may induce free cholesterol accumulation in the endoplasmic reticulum and subsequently stimulate ERS and activate the UPR signaling pathway mediated by ATF6 and IRE1 in macrophages, a process that is potentially mediated by TLR4." @default.
• W1982210884 created "2016-06-24" @default.
• W1982210884 creator A5001003276 @default.
• W1982210884 creator A5030685215 @default.
• W1982210884 creator A5040357722 @default.
• W1982210884 creator A5042973046 @default.
• W1982210884 creator A5046199656 @default.
• W1982210884 creator A5068186967 @default.
• W1982210884 creator A5085098106 @default.
• W1982210884 creator A5091554768 @default.
• W1982210884 date "2012-07-01" @default.
• W1982210884 modified "2023-09-29" @default.
• W1982210884 title "Minimally modified low-density lipoprotein induces macrophage endoplasmic reticulum stress via toll-like receptor 4" @default.
• W1982210884 cites W1591398790 @default.
• W1982210884 cites W1965662126 @default.
• W1982210884 cites W1966217960 @default.
• W1982210884 cites W1969587274 @default.
• W1982210884 cites W1970090817 @default.
• W1982210884 cites W1975370063 @default.
• W1982210884 cites W1997860537 @default.
• W1982210884 cites W2010381644 @default.
• W1982210884 cites W2021368537 @default.
• W1982210884 cites W2028215693 @default.
• W1982210884 cites W2028992794 @default.
• W1982210884 cites W2029328009 @default.
• W1982210884 cites W2033891772 @default.
• W1982210884 cites W2036615309 @default.
• W1982210884 cites W2036746876 @default.
• W1982210884 cites W2038257183 @default.
• W1982210884 cites W2052848320 @default.
• W1982210884 cites W2069709543 @default.
• W1982210884 cites W2106314483 @default.
• W1982210884 cites W2113937251 @default.
• W1982210884 cites W2118763051 @default.
• W1982210884 cites W2120646963 @default.
• W1982210884 cites W2123177387 @default.
• W1982210884 cites W2125938633 @default.
• W1982210884 cites W2136751995 @default.
• W1982210884 cites W2137511741 @default.
• W1982210884 cites W2140187466 @default.
• W1982210884 cites W2142174657 @default.
• W1982210884 cites W2143789702 @default.
• W1982210884 cites W2165436546 @default.
• W1982210884 doi "https://doi.org/10.1016/j.bbalip.2012.03.003" @default.
• W1982210884 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22480542" @default.
• W1982210884 hasPublicationYear "2012" @default.
• W1982210884 type Work @default.
• W1982210884 sameAs 1982210884 @default.
• W1982210884 citedByCount "22" @default.
• W1982210884 countsByYear W19822108842014 @default.
• W1982210884 countsByYear W19822108842015 @default.
• W1982210884 countsByYear W19822108842016 @default.
• W1982210884 countsByYear W19822108842017 @default.
• W1982210884 countsByYear W19822108842018 @default.
• W1982210884 countsByYear W19822108842019 @default.
• W1982210884 countsByYear W19822108842020 @default.
• W1982210884 countsByYear W19822108842021 @default.
• W1982210884 countsByYear W19822108842022 @default.
• W1982210884 countsByYear W19822108842023 @default.
• W1982210884 crossrefType "journal-article" @default.
• W1982210884 hasAuthorship W1982210884A5001003276 @default.
• W1982210884 hasAuthorship W1982210884A5030685215 @default.
• W1982210884 hasAuthorship W1982210884A5040357722 @default.
• W1982210884 hasAuthorship W1982210884A5042973046 @default.
• W1982210884 hasAuthorship W1982210884A5046199656 @default.
• W1982210884 hasAuthorship W1982210884A5068186967 @default.
• W1982210884 hasAuthorship W1982210884A5085098106 @default.
• W1982210884 hasAuthorship W1982210884A5091554768 @default.
• W1982210884 hasConcept C104317684 @default.
• W1982210884 hasConcept C127561419 @default.
• W1982210884 hasConcept C139447449 @default.
• W1982210884 hasConcept C158617107 @default.
• W1982210884 hasConcept C170493617 @default.
• W1982210884 hasConcept C185592680 @default.
• W1982210884 hasConcept C2776070231 @default.
• W1982210884 hasConcept C2778163477 @default.
• W1982210884 hasConcept C2778997996 @default.
• W1982210884 hasConcept C2779828298 @default.
• W1982210884 hasConcept C2780072125 @default.
• W1982210884 hasConcept C43554185 @default.
• W1982210884 hasConcept C55493867 @default.
• W1982210884 hasConcept C62478195 @default.
• W1982210884 hasConcept C86803240 @default.
• W1982210884 hasConcept C95444343 @default.
• W1982210884 hasConceptScore W1982210884C104317684 @default.
• W1982210884 hasConceptScore W1982210884C127561419 @default.
• W1982210884 hasConceptScore W1982210884C139447449 @default.
• W1982210884 hasConceptScore W1982210884C158617107 @default.
• W1982210884 hasConceptScore W1982210884C170493617 @default.
• W1982210884 hasConceptScore W1982210884C185592680 @default.
• W1982210884 hasConceptScore W1982210884C2776070231 @default.
• W1982210884 hasConceptScore W1982210884C2778163477 @default.
• W1982210884 hasConceptScore W1982210884C2778997996 @default.
• W1982210884 hasConceptScore W1982210884C2779828298 @default.
• W1982210884 hasConceptScore W1982210884C2780072125 @default.
• W1982210884 hasConceptScore W1982210884C43554185 @default.
• W1982210884 hasConceptScore W1982210884C55493867 @default.
• W1982210884 hasConceptScore W1982210884C62478195 @default.

• next