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- W1982221602 abstract "Background & Aims: Acute inflammatory ileitis occurs in susceptible (C57BL/6) mice after oral infection with Toxoplasma gondii. Overproduction of interferon (IFN)-γ and synthesis of nitric oxide mediate the inflammation. We evaluated the role of transforming growth factor (TGF)-β produced by intraepithelial lymphocytes (IELs) in this process. Methods: We analyzed the histologic and immunologic consequences of adoptive transfer of antigen-primed IELs into susceptible mice treated with anti–TGF-β before oral challenge with T. gondii cysts. An in vitro coculture of enterocytes and IELs assessed the production of chemokines and cytokines in the presence of anti–TGF-β. Results: Antigen-primed IELs prevent acute ileitis in susceptible mice that is reversed with anti–TGF-β. Resistant mice (CBA/J) develop ileitis after treatment with anti–TGF-β. Antigen-primed IELs can induce systemic immunosuppression as measured by depressed IFN-γ production. In vitro, primed IELs reduce the production of inflammatory chemokines by infected enterocytes and IFN-γ by splenocytes. Conclusions: Regulation of the ileal inflammatory process resulting from T. gondii is dependent on TGF-β–producing IELs. The IELs are an essential component in gut homeostasis after oral infection with this parasite.GASTROENTEROLOGY 2001;120:914-924" @default.
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- W1982221602 date "2001-03-01" @default.
- W1982221602 modified "2023-10-17" @default.
- W1982221602 title "Murine ileitis after intracellular parasite infection is controlled by TGF-β–producing intraepithelial lymphocytes" @default.
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- W1982221602 doi "https://doi.org/10.1053/gast.2001.22432a" @default.
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