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• W1982241922 endingPage "1241" @default.
• W1982241922 startingPage "1233" @default.
• W1982241922 abstract "Heat shock proteins (HSPs) in their molecular capacity as chaperones have been reported to regulate the apoptotic pathway and also play a critical role in protein conformational diseases such as Alzheimer's disease (AD). As all Down syndrome (DS) brains display AD-like neuropathology, neuronal loss in DS was shown to be mediated by apoptosis. We decided to investigate the expression patterns of HSPs in seven brain regions of adults with DS using two-dimensional polyacrylamide gel electrophoresis (2-DE). Following 2-DE, approximately 120 protein spots were successfully identified by matrix-assisted laser desorption/ionization--mass spectrometry (MALDI-MS) followed by quantification of the identified proteins. We unambiguously identified and quantified nine different chaperone proteins. Accordingly, all but three chaperone proteins did exhibit a significant change in expression. HSP 70 RY, heat shock cognate (HSC) 71 and glucose-regulated protein (GRP) 75 showed a significant decrease (P < 0.05) in DS temporal cortex whereas HSP 70.1 and GRP 78 were significantly increased (P<0.05) in cerebellum. Whilst T-complex 1 (TCP-1) epsilon subunit showed a significant decrease (P< 0.05) in parietal cortex, a similar extent of increase (P<0.05) as that observed in cerebellum was obtained in parietal levels of GRP 78. Alpha-crystallin B, HSP 60 and GRP 94 did not show any detectable changes in expression patterns. This report presents the first approach to quantify nine different chaperones simultaneously at the protein level in different brain regions and provides evidence for aberrant chaperone expression patterns in DS. The relevance of this aberrant expression patterns are discussed in relation to the biochemical and neuropathological abnormalities in DS brain." @default.
• W1982241922 created "2016-06-24" @default.
• W1982241922 creator A5009134770 @default.
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• W1982241922 date "2001-04-01" @default.
• W1982241922 modified "2023-09-24" @default.
• W1982241922 title "Differential expression of molecular chaperones in brain of patients with Down syndrome" @default.
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• W1982241922 doi "https://doi.org/10.1002/1522-2683()22:6<1233::aid-elps1233>3.0.co;2-m" @default.
• W1982241922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11358150" @default.
• W1982241922 hasPublicationYear "2001" @default.
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