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• W1982243334 endingPage "228" @default.
• W1982243334 startingPage "221" @default.
• W1982243334 abstract "In this study we examined a possible contribution of serotonin (5-hydroxytryptamine, 5-HT) to spatial memory performance in the rat. Rats were trained to run in a radial maze in a manner that involved two kinds of memory function, i.e. working memory and reference memory. They received intrahippocampal microinjections of a 5-HT1A [8-hydroxy-2-(di-n-propylamino)tetralin or 8-OH-DPAT], or a 5-HT1B [3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one or CP-93,129] receptor agonist, and a muscarinic receptor antagonist (scopolamine). 8-OH-DPAT (5 micrograms/microliters), like injections of saline, induced no change in performance levels. In contrast, rats suffered an impairment in both reference and working memory following injection of scopolamine (10 micrograms/microliters). CP-93,129 induced a higher frequency of reference memory errors than of working memory errors at the intermediate (10 micrograms/microliters) and higher doses (16 micrograms/microliters). Thus, the stimulation of 5-HT1B receptors in the CA1 field of the dorsal hippocampus impairs the performance of rats in a spatial learning task." @default.
• W1982243334 created "2016-06-24" @default.
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• W1982243334 creator A5025224183 @default.
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• W1982243334 date "1995-10-01" @default.
• W1982243334 modified "2023-10-12" @default.
• W1982243334 title "Spatial memory deficits following stimulation of hippocampal 5-HT1B receptors in the rat" @default.
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• W1982243334 doi "https://doi.org/10.1016/0014-2999(95)00407-c" @default.
• W1982243334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8575507" @default.
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