FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982243668> ?p ?o ?g. }

• W1982243668 endingPage "3848" @default.
• W1982243668 startingPage "3843" @default.
• W1982243668 abstract "Activation-induced cytosine deaminase (AID) is essential for both somatic hypermutation (SHM) and class switch recombination (CSR), two processes involved in antibody diversification. Previously, various groups showed both in vitro and in vivo that AID initiates SHM and CSR by deaminating cytosines in DNA in a transcription-dependent manner. Although in vivo both DNA strands are equally targeted by AID, many in vitro and bacterial experiments found that AID almost exclusively targets the nontemplate strand of a transcribed substrate. Here, we report the detection of antisense transcripts in assembled Ig heavy chain (IgH) variable region exons and their immediate downstream region, as well as in switch regions, sequences that, respectively, are targets for SHM and CSR in vivo . In contrast, we did not detect antisense transcripts from the Cμ constant region exons, which lie between the IgH variable region exons and downstream S regions and which are not normally an AID target. Expression of the antisense variable region/flanking region and the S-region transcripts were found in all lymphocytes that transcribe these sequences in the sense direction. Steady-state levels of antisense transcripts appeared very low, and start sites potentially appeared heterogeneous. We discuss the potential implications of antisense IgH locus transcription for AID targeting or other processes." @default.
• W1982243668 created "2016-06-24" @default.
• W1982243668 creator A5028730363 @default.
• W1982243668 creator A5033821931 @default.
• W1982243668 creator A5074942308 @default.
• W1982243668 date "2008-03-11" @default.
• W1982243668 modified "2023-09-23" @default.
• W1982243668 title "Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regions" @default.
• W1982243668 cites W1495338298 @default.
• W1982243668 cites W1504583071 @default.
• W1982243668 cites W1554669615 @default.
• W1982243668 cites W1686333409 @default.
• W1982243668 cites W1923349335 @default.
• W1982243668 cites W1954469784 @default.
• W1982243668 cites W1970966311 @default.
• W1982243668 cites W1972397361 @default.
• W1982243668 cites W1974360297 @default.
• W1982243668 cites W1980889239 @default.
• W1982243668 cites W2005485091 @default.
• W1982243668 cites W2008073080 @default.
• W1982243668 cites W2015414930 @default.
• W1982243668 cites W2022186577 @default.
• W1982243668 cites W2024303560 @default.
• W1982243668 cites W2028010103 @default.
• W1982243668 cites W2029844299 @default.
• W1982243668 cites W2029864255 @default.
• W1982243668 cites W2031404451 @default.
• W1982243668 cites W2032288627 @default.
• W1982243668 cites W2036806870 @default.
• W1982243668 cites W2047852652 @default.
• W1982243668 cites W2059557296 @default.
• W1982243668 cites W2066874028 @default.
• W1982243668 cites W2067961064 @default.
• W1982243668 cites W2070341297 @default.
• W1982243668 cites W2073622904 @default.
• W1982243668 cites W2075525218 @default.
• W1982243668 cites W2094011807 @default.
• W1982243668 cites W2094094914 @default.
• W1982243668 cites W2098643655 @default.
• W1982243668 cites W2099984871 @default.
• W1982243668 cites W2101868807 @default.
• W1982243668 cites W2116003600 @default.
• W1982243668 cites W2127462192 @default.
• W1982243668 cites W2129883110 @default.
• W1982243668 cites W2150010396 @default.
• W1982243668 cites W2160640824 @default.
• W1982243668 cites W2165608602 @default.
• W1982243668 cites W2169107624 @default.
• W1982243668 cites W2169474275 @default.
• W1982243668 cites W2171690009 @default.
• W1982243668 cites W4256562182 @default.
• W1982243668 doi "https://doi.org/10.1073/pnas.0712291105" @default.
• W1982243668 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2268805" @default.
• W1982243668 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18292225" @default.
• W1982243668 hasPublicationYear "2008" @default.
• W1982243668 type Work @default.
• W1982243668 sameAs 1982243668 @default.
• W1982243668 citedByCount "59" @default.
• W1982243668 countsByYear W19822436682012 @default.
• W1982243668 countsByYear W19822436682013 @default.
• W1982243668 countsByYear W19822436682014 @default.
• W1982243668 countsByYear W19822436682015 @default.
• W1982243668 countsByYear W19822436682016 @default.
• W1982243668 countsByYear W19822436682017 @default.
• W1982243668 countsByYear W19822436682018 @default.
• W1982243668 countsByYear W19822436682019 @default.
• W1982243668 countsByYear W19822436682021 @default.
• W1982243668 countsByYear W19822436682022 @default.
• W1982243668 countsByYear W19822436682023 @default.
• W1982243668 crossrefType "journal-article" @default.
• W1982243668 hasAuthorship W1982243668A5028730363 @default.
• W1982243668 hasAuthorship W1982243668A5033821931 @default.
• W1982243668 hasAuthorship W1982243668A5074942308 @default.
• W1982243668 hasBestOaLocation W19822436681 @default.
• W1982243668 hasConcept C104317684 @default.
• W1982243668 hasConcept C128526571 @default.
• W1982243668 hasConcept C137756551 @default.
• W1982243668 hasConcept C138885662 @default.
• W1982243668 hasConcept C150194340 @default.
• W1982243668 hasConcept C153911025 @default.
• W1982243668 hasConcept C159654299 @default.
• W1982243668 hasConcept C179926584 @default.
• W1982243668 hasConcept C202416437 @default.
• W1982243668 hasConcept C2776985229 @default.
• W1982243668 hasConcept C2778453870 @default.
• W1982243668 hasConcept C36823959 @default.
• W1982243668 hasConcept C41895202 @default.
• W1982243668 hasConcept C54355233 @default.
• W1982243668 hasConcept C84597430 @default.
• W1982243668 hasConcept C86803240 @default.
• W1982243668 hasConcept C96007430 @default.
• W1982243668 hasConceptScore W1982243668C104317684 @default.
• W1982243668 hasConceptScore W1982243668C128526571 @default.
• W1982243668 hasConceptScore W1982243668C137756551 @default.
• W1982243668 hasConceptScore W1982243668C138885662 @default.
• W1982243668 hasConceptScore W1982243668C150194340 @default.
• W1982243668 hasConceptScore W1982243668C153911025 @default.
• W1982243668 hasConceptScore W1982243668C159654299 @default.

• next