Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982245968> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1982245968 endingPage "65" @default.
- W1982245968 startingPage "62" @default.
- W1982245968 abstract "Living systems are mainly composed and regulated by compounds in four biochemical classes and their polymers—nucleotides, carbohydrates, lipids, and amino acids. Early combinatorial chemistry libraries consisted of peptides. The present report describes the general bioactivity and biophysical properties of a combinatorial chemical library that used glyco, nucleotidyl, and lipid building blocks. The resulting chimeric combinatorial library of 361 compounds had a confirmed cumulative hit rate of 0.16%, which is 8-fold higher than a commonly claimed industrial benchmark of 0.02%. It produced 7 structurally confirmed hits for a third of 12 proprietary drug discovery projects, and these comprised a variety of molecular targets. Diversity analyses demonstrated that despite the small number of compounds, a wider range of diversity space was covered by this library of biochemical chimeras than by a branched tripeptide library of the same size and similar generic formula." @default.
- W1982245968 created "2016-06-24" @default.
- W1982245968 creator A5001037071 @default.
- W1982245968 creator A5018129110 @default.
- W1982245968 creator A5030871076 @default.
- W1982245968 creator A5049935008 @default.
- W1982245968 creator A5057764841 @default.
- W1982245968 creator A5062471830 @default.
- W1982245968 creator A5070420565 @default.
- W1982245968 creator A5072821930 @default.
- W1982245968 creator A5078988280 @default.
- W1982245968 creator A5081996199 @default.
- W1982245968 creator A5082336140 @default.
- W1982245968 creator A5083809667 @default.
- W1982245968 creator A5090886714 @default.
- W1982245968 creator A5090921919 @default.
- W1982245968 date "1999-12-01" @default.
- W1982245968 modified "2023-10-08" @default.
- W1982245968 title "Efficient Discovery of Inhibitory Ligands for Diverse Targets from a Small Combinatorial Chemical Library of Chimeric Molecules" @default.
- W1982245968 cites W167238971 @default.
- W1982245968 cites W1963790256 @default.
- W1982245968 cites W1971231281 @default.
- W1982245968 cites W1989624186 @default.
- W1982245968 cites W2006446936 @default.
- W1982245968 cites W2008923259 @default.
- W1982245968 cites W2029134389 @default.
- W1982245968 cites W2039670698 @default.
- W1982245968 cites W2060553176 @default.
- W1982245968 cites W4248107770 @default.
- W1982245968 doi "https://doi.org/10.1006/bbrc.1999.1775" @default.
- W1982245968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10581165" @default.
- W1982245968 hasPublicationYear "1999" @default.
- W1982245968 type Work @default.
- W1982245968 sameAs 1982245968 @default.
- W1982245968 citedByCount "7" @default.
- W1982245968 countsByYear W19822459682022 @default.
- W1982245968 countsByYear W19822459682023 @default.
- W1982245968 crossrefType "journal-article" @default.
- W1982245968 hasAuthorship W1982245968A5001037071 @default.
- W1982245968 hasAuthorship W1982245968A5018129110 @default.
- W1982245968 hasAuthorship W1982245968A5030871076 @default.
- W1982245968 hasAuthorship W1982245968A5049935008 @default.
- W1982245968 hasAuthorship W1982245968A5057764841 @default.
- W1982245968 hasAuthorship W1982245968A5062471830 @default.
- W1982245968 hasAuthorship W1982245968A5070420565 @default.
- W1982245968 hasAuthorship W1982245968A5072821930 @default.
- W1982245968 hasAuthorship W1982245968A5078988280 @default.
- W1982245968 hasAuthorship W1982245968A5081996199 @default.
- W1982245968 hasAuthorship W1982245968A5082336140 @default.
- W1982245968 hasAuthorship W1982245968A5083809667 @default.
- W1982245968 hasAuthorship W1982245968A5090886714 @default.
- W1982245968 hasAuthorship W1982245968A5090921919 @default.
- W1982245968 hasConcept C161624437 @default.
- W1982245968 hasConcept C167392928 @default.
- W1982245968 hasConcept C185592680 @default.
- W1982245968 hasConcept C21951064 @default.
- W1982245968 hasConcept C2779057010 @default.
- W1982245968 hasConcept C2994224535 @default.
- W1982245968 hasConcept C515207424 @default.
- W1982245968 hasConcept C55493867 @default.
- W1982245968 hasConcept C70721500 @default.
- W1982245968 hasConcept C71240020 @default.
- W1982245968 hasConcept C74187038 @default.
- W1982245968 hasConcept C86803240 @default.
- W1982245968 hasConcept C99726746 @default.
- W1982245968 hasConceptScore W1982245968C161624437 @default.
- W1982245968 hasConceptScore W1982245968C167392928 @default.
- W1982245968 hasConceptScore W1982245968C185592680 @default.
- W1982245968 hasConceptScore W1982245968C21951064 @default.
- W1982245968 hasConceptScore W1982245968C2779057010 @default.
- W1982245968 hasConceptScore W1982245968C2994224535 @default.
- W1982245968 hasConceptScore W1982245968C515207424 @default.
- W1982245968 hasConceptScore W1982245968C55493867 @default.
- W1982245968 hasConceptScore W1982245968C70721500 @default.
- W1982245968 hasConceptScore W1982245968C71240020 @default.
- W1982245968 hasConceptScore W1982245968C74187038 @default.
- W1982245968 hasConceptScore W1982245968C86803240 @default.
- W1982245968 hasConceptScore W1982245968C99726746 @default.
- W1982245968 hasIssue "1" @default.
- W1982245968 hasLocation W19822459681 @default.
- W1982245968 hasLocation W19822459682 @default.
- W1982245968 hasOpenAccess W1982245968 @default.
- W1982245968 hasPrimaryLocation W19822459681 @default.
- W1982245968 hasRelatedWork W2034722072 @default.
- W1982245968 hasRelatedWork W2295441452 @default.
- W1982245968 hasRelatedWork W2386492977 @default.
- W1982245968 hasRelatedWork W2399432342 @default.
- W1982245968 hasRelatedWork W2487343495 @default.
- W1982245968 hasRelatedWork W2896982708 @default.
- W1982245968 hasRelatedWork W2904031697 @default.
- W1982245968 hasRelatedWork W2921492615 @default.
- W1982245968 hasRelatedWork W3035079691 @default.
- W1982245968 hasRelatedWork W4385760073 @default.
- W1982245968 hasVolume "266" @default.
- W1982245968 isParatext "false" @default.
- W1982245968 isRetracted "false" @default.
- W1982245968 magId "1982245968" @default.
- W1982245968 workType "article" @default.