FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982248148> ?p ?o ?g. }

• W1982248148 abstract "Prometheus gave mankind wisdom and then suffered the consequences; his liver was eaten each night by eagles and regenerated each day. Surgeons educated by this tale have been resecting liver tumors for years and seeing improve- ment in patients' survival. The criteria for liver resection in patients with metastatic colorectal cancer have undergone a metamorphosis over the last 50 years with even broader boundaries. In Viganoet al.'s 1 article in this issue of the Annals of Surgical Oncology, another potential barrier to liver resection may have been lifted. They report that even for patients whose tumor progresses on chemotherapy, there is benefit from hepatic resection. Previous reports of resection in patients with tumor progression have had poor results. 2,3 Some of the studies may have been too small or had inadequate long-term follow-up. One such report ini- tially described poor results, but on further follow-up and with inclusion of more patients, the authors concluded that there was no difference in survival after liver resection between those whose tumor responded or progressed after neoadjuvant chemotherapy. This may reflect a cautionary tale about retrospective studies that are too small or do not report long-term follow-up. The strength of this report is that it is a large multi-institutional study. 1 Of the 2,143 patients undergoing hepatic resection, 176 patients expe- rienced tumor progression while on systemic neoadjuvant chemotherapy and still had a 35 % 5-year survival. How- ever, since the median follow-up is only 27 months, and most patients in the study were entered after 2006 with data collection stopping in 2010, the 5-year survival is only a projected number. If these results hold up after longer follow-up, Viganoet al.'s study would provide strong support for the use of regional therapy, in this case, hepatic resection, in patients with hepatic-only colorectal metas- tases. An MSKCC study, looking at the question of responders versus nonresponders to chemotherapy prior to liver resection reported no difference in survival in the two groups (59 vs 61 months for the responders vs progression, respectively), with a follow-up time of 63 months. 4 The MSKCC study was a single-institution study where 80 % of patients received postoperative (postop) therapy and 40 % postop hepatic arterial infusion (HAI). The patients whose tumor progressed in the MSKCC study were more likely to have positive margins when undergoing liver resection, a factor not reviewed in the Viganostudy. Vi- gano `'s report also stated that poor-risk patients (more than three metastases, lesions greater than 5 cm, or those with CEA higher than 200 ng/ml) should be treated with further chemotherapy prior to consideration of hepatic resection. Is further systemic chemotherapy useful? Second-line systemic chemotherapy has a low response rate averaging 20 % (range 11-35 %). 5 The median survival from starting second line treatment is about 11 months (range 9-14 months). 5 In Viganoet al.'s analysis, patients who progressed on chemotherapy with one negative factor such as more than three liver metastases have a 29.9 % 5-year survival when they undergo hepatic resection. The chances of being alive at even 3 years with further systemic therapy if a patient has tumor progression on first-line systemic chemotherapy and has poor risk factors is less than 1 %. Use of regional therapy with HAI after progression on systemic therapy may be a more useful approach. Using HAI oxaliplatin and systemic fluorouracil/leucovorin (FU/ LV), Ducreux et al. 6 observed a 64 % response rate in a group of patients where 81 % had not responded to prior systemic chemotherapy. At MSKCC, patients with unre- sectable disease who had received previous systemic chemotherapy and then received HAI-FUDR/dexametha- sone and systemic (SYS) oxaliplatin/irinotecan had a tumor response rate of 85 % with a median survival of 35 months from the time of initiation of HAI. 7 The major toxicities of" @default.
• W1982248148 created "2016-06-24" @default.
• W1982248148 creator A5069644669 @default.
• W1982248148 date "2012-07-03" @default.
• W1982248148 modified "2023-10-16" @default.
• W1982248148 title "Changing Paradigms for Liver Resection of Colorectal Metastases" @default.
• W1982248148 cites W1489195779 @default.
• W1982248148 cites W1835268604 @default.
• W1982248148 cites W1966397080 @default.
• W1982248148 cites W1979170197 @default.
• W1982248148 cites W1979423262 @default.
• W1982248148 cites W1980328802 @default.
• W1982248148 cites W1985524610 @default.
• W1982248148 cites W1989053425 @default.
• W1982248148 cites W1989175303 @default.
• W1982248148 cites W1999265843 @default.
• W1982248148 cites W2025410458 @default.
• W1982248148 cites W2045102926 @default.
• W1982248148 cites W2054265070 @default.
• W1982248148 cites W2066390717 @default.
• W1982248148 cites W2082824264 @default.
• W1982248148 cites W2084470612 @default.
• W1982248148 cites W2104614485 @default.
• W1982248148 cites W2120044571 @default.
• W1982248148 cites W2131239494 @default.
• W1982248148 cites W2131745440 @default.
• W1982248148 cites W2138235363 @default.
• W1982248148 cites W2155854000 @default.
• W1982248148 cites W2168460655 @default.
• W1982248148 cites W2316178638 @default.
• W1982248148 cites W2092731249 @default.
• W1982248148 doi "https://doi.org/10.1245/s10434-012-2463-7" @default.
• W1982248148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22752377" @default.
• W1982248148 hasPublicationYear "2012" @default.
• W1982248148 type Work @default.
• W1982248148 sameAs 1982248148 @default.
• W1982248148 citedByCount "2" @default.
• W1982248148 countsByYear W19822481482014 @default.
• W1982248148 countsByYear W19822481482016 @default.
• W1982248148 crossrefType "journal-article" @default.
• W1982248148 hasAuthorship W1982248148A5069644669 @default.
• W1982248148 hasBestOaLocation W19822481481 @default.
• W1982248148 hasConcept C121608353 @default.
• W1982248148 hasConcept C126322002 @default.
• W1982248148 hasConcept C141071460 @default.
• W1982248148 hasConcept C143998085 @default.
• W1982248148 hasConcept C159110652 @default.
• W1982248148 hasConcept C167135981 @default.
• W1982248148 hasConcept C2776694085 @default.
• W1982248148 hasConcept C2776909242 @default.
• W1982248148 hasConcept C2780120127 @default.
• W1982248148 hasConcept C2780140570 @default.
• W1982248148 hasConcept C523026621 @default.
• W1982248148 hasConcept C526805850 @default.
• W1982248148 hasConcept C61434518 @default.
• W1982248148 hasConcept C71924100 @default.
• W1982248148 hasConceptScore W1982248148C121608353 @default.
• W1982248148 hasConceptScore W1982248148C126322002 @default.
• W1982248148 hasConceptScore W1982248148C141071460 @default.
• W1982248148 hasConceptScore W1982248148C143998085 @default.
• W1982248148 hasConceptScore W1982248148C159110652 @default.
• W1982248148 hasConceptScore W1982248148C167135981 @default.
• W1982248148 hasConceptScore W1982248148C2776694085 @default.
• W1982248148 hasConceptScore W1982248148C2776909242 @default.
• W1982248148 hasConceptScore W1982248148C2780120127 @default.
• W1982248148 hasConceptScore W1982248148C2780140570 @default.
• W1982248148 hasConceptScore W1982248148C523026621 @default.
• W1982248148 hasConceptScore W1982248148C526805850 @default.
• W1982248148 hasConceptScore W1982248148C61434518 @default.
• W1982248148 hasConceptScore W1982248148C71924100 @default.
• W1982248148 hasLocation W19822481481 @default.
• W1982248148 hasLocation W19822481482 @default.
• W1982248148 hasOpenAccess W1982248148 @default.
• W1982248148 hasPrimaryLocation W19822481481 @default.
• W1982248148 hasRelatedWork W1976368237 @default.
• W1982248148 hasRelatedWork W2016991845 @default.
• W1982248148 hasRelatedWork W2062762630 @default.
• W1982248148 hasRelatedWork W2089615154 @default.
• W1982248148 hasRelatedWork W2537750982 @default.
• W1982248148 hasRelatedWork W2590678893 @default.
• W1982248148 hasRelatedWork W403758582 @default.
• W1982248148 hasRelatedWork W4226133302 @default.
• W1982248148 hasRelatedWork W54669808 @default.
• W1982248148 hasRelatedWork W582475673 @default.
• W1982248148 isParatext "false" @default.
• W1982248148 isRetracted "false" @default.
• W1982248148 magId "1982248148" @default.
• W1982248148 workType "article" @default.