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• W1982253507 endingPage "112" @default.
• W1982253507 startingPage "100" @default.
• W1982253507 abstract "There are two types of adipose tissue in the body whose function appears to be clearly differentiated. White adipose tissue stores energy reserves as fat, whereas the metabolic function of brown adipose tissue is lipid oxidation to produce heat. A good balance between them is important to maintain energy homeostasis. The concept of white adipose tissue has radically changed in the past decades, and is now considered as an endocrine organ that secretes many factors with autocrine, paracrine, and endocrine functions. In addition, we can no longer consider white adipose tissue as a single tissue, because it shows different metabolic profiles in its different locations, with also different implications. Although the characteristic cell of adipose tissue is the adipocyte, this is not the only cell type present in adipose tissue, neither the most abundant. Other cell types in adipose tissue described include stem cells, preadipocytes, macrophages, neutrophils, lymphocytes, and endothelial cells. The balance between these different cell types and their expression profile is closely related to maintenance of energy homeostasis. Increases in adipocyte size, number and type of lymphocytes, and infiltrated macrophages are closely related to the metabolic syndrome diseases. The study of regulation of proliferation and differentiation of preadipocytes and stem cells, and understanding of the interrelationship between the different cell types will provide new targets for action against these diseases." @default.
• W1982253507 created "2016-06-24" @default.
• W1982253507 creator A5080628188 @default.
• W1982253507 date "2014-02-01" @default.
• W1982253507 modified "2023-10-11" @default.
• W1982253507 title "Adipose tissue: Cell heterogeneity and functional diversity" @default.
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• W1982253507 doi "https://doi.org/10.1016/j.endoen.2014.02.001" @default.
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