Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982255698> ?p ?o ?g. }
- W1982255698 endingPage "969" @default.
- W1982255698 startingPage "959" @default.
- W1982255698 abstract "Objectives: To determine which serotonergic system-related single nucleotide polymorphisms (SNPs) predicted variation in treatment response to citalopram in depression following a traumatic brain injury (TBI).Methods: Ninety (50 M/40 F, aged 39.9, SD = 18.0 years) post-TBI patients with a major depressive episode (MDE) were recruited into a 6-week open-label study of citalopram (20 mg/day). Six functional SNPs in genes related to the serotonergic system were examined: serotonin transporter (5HTTLPR including rs25531), 5HT1A C-(1019)G and 5HT2A T-(102)C, methylene tetrahydrofolate reductase (MTHFR) C-(677)T, brain-derived neurotrophic factor (BDNF) val66met and tryptophan hydroxylase-2 (TPH2) G-(703)T. Regression analyses were performed using the six SNPs as independent variables: Model 1 with response (percentage Hamilton Depression (HAMD) change from baseline to endpoint) as the dependent variable and Model 2 with adverse event index as the dependent variable (Bonferroni corrected p-value < 0.025).Results: MTHFR and BDNF SNPs predicted greater treatment response (R2= 0.098, F = 4.65, p = 0.013). The 5HTTLPR predicted greater occurrence of adverse events (R2= 0.069, F = 5.72, p = 0.020).Conclusion: Results suggest that polymorphisms in genes related to the serotonergic system may help predict short-term response to citalopram and tolerability to the medication in patients with MDE following a TBI." @default.
- W1982255698 created "2016-06-24" @default.
- W1982255698 creator A5001416804 @default.
- W1982255698 creator A5003023635 @default.
- W1982255698 creator A5009489323 @default.
- W1982255698 creator A5028848754 @default.
- W1982255698 creator A5041525482 @default.
- W1982255698 creator A5056370228 @default.
- W1982255698 creator A5056420149 @default.
- W1982255698 creator A5076741931 @default.
- W1982255698 creator A5084258053 @default.
- W1982255698 creator A5084529068 @default.
- W1982255698 creator A5085885383 @default.
- W1982255698 creator A5090782173 @default.
- W1982255698 date "2010-06-01" @default.
- W1982255698 modified "2023-10-17" @default.
- W1982255698 title "Genetic predictors of response to treatment with citalopram in depression secondary to traumatic brain injury" @default.
- W1982255698 cites W1835825865 @default.
- W1982255698 cites W1850225444 @default.
- W1982255698 cites W1966161647 @default.
- W1982255698 cites W1966956312 @default.
- W1982255698 cites W1968213313 @default.
- W1982255698 cites W1970159591 @default.
- W1982255698 cites W1976555550 @default.
- W1982255698 cites W1978505907 @default.
- W1982255698 cites W1980437773 @default.
- W1982255698 cites W1981684805 @default.
- W1982255698 cites W1982886582 @default.
- W1982255698 cites W1984135336 @default.
- W1982255698 cites W1984455353 @default.
- W1982255698 cites W1989741780 @default.
- W1982255698 cites W1990630086 @default.
- W1982255698 cites W1993636230 @default.
- W1982255698 cites W1997594680 @default.
- W1982255698 cites W2005534453 @default.
- W1982255698 cites W2008750230 @default.
- W1982255698 cites W2011189941 @default.
- W1982255698 cites W2014737049 @default.
- W1982255698 cites W2024142896 @default.
- W1982255698 cites W2028786180 @default.
- W1982255698 cites W2028850322 @default.
- W1982255698 cites W2029278453 @default.
- W1982255698 cites W2031831813 @default.
- W1982255698 cites W2035120573 @default.
- W1982255698 cites W2035689377 @default.
- W1982255698 cites W2042170262 @default.
- W1982255698 cites W2047200908 @default.
- W1982255698 cites W2049098623 @default.
- W1982255698 cites W2050042714 @default.
- W1982255698 cites W2053578577 @default.
- W1982255698 cites W2053730389 @default.
- W1982255698 cites W2059483509 @default.
- W1982255698 cites W2062113276 @default.
- W1982255698 cites W2070285161 @default.
- W1982255698 cites W2071660247 @default.
- W1982255698 cites W2077254617 @default.
- W1982255698 cites W2077306993 @default.
- W1982255698 cites W2077425100 @default.
- W1982255698 cites W2078823477 @default.
- W1982255698 cites W2081143676 @default.
- W1982255698 cites W2088149800 @default.
- W1982255698 cites W2089198034 @default.
- W1982255698 cites W2089551905 @default.
- W1982255698 cites W2092483401 @default.
- W1982255698 cites W2093154571 @default.
- W1982255698 cites W2098231907 @default.
- W1982255698 cites W2098760758 @default.
- W1982255698 cites W2100549080 @default.
- W1982255698 cites W2105841861 @default.
- W1982255698 cites W2106095564 @default.
- W1982255698 cites W2106885532 @default.
- W1982255698 cites W2111424618 @default.
- W1982255698 cites W2114613490 @default.
- W1982255698 cites W2119618076 @default.
- W1982255698 cites W2130311440 @default.
- W1982255698 cites W2135916631 @default.
- W1982255698 cites W2136277044 @default.
- W1982255698 cites W2137792998 @default.
- W1982255698 cites W2141106789 @default.
- W1982255698 cites W2146599657 @default.
- W1982255698 cites W2150517983 @default.
- W1982255698 cites W2151135161 @default.
- W1982255698 cites W2152686085 @default.
- W1982255698 cites W2153606794 @default.
- W1982255698 cites W2156217610 @default.
- W1982255698 cites W2157877920 @default.
- W1982255698 cites W2162214930 @default.
- W1982255698 cites W2170201062 @default.
- W1982255698 cites W2171321056 @default.
- W1982255698 cites W2324429656 @default.
- W1982255698 cites W2406697481 @default.
- W1982255698 cites W24345798 @default.
- W1982255698 cites W2606481147 @default.
- W1982255698 cites W2914151665 @default.
- W1982255698 cites W4297243831 @default.
- W1982255698 cites W4368281319 @default.
- W1982255698 doi "https://doi.org/10.3109/02699051003789229" @default.
- W1982255698 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3142269" @default.