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• W1982258274 endingPage "e89" @default.
• W1982258274 startingPage "e89" @default.
• W1982258274 abstract "In 1998, the Food and Drug Administration (FDA) approved the licensure of tobramycin solution for inhalation (TOBI). Although a number of additional antibiotics, including other aminoglycosides, beta-lactams, antibiotics in the polymyxin class, and vancomycin, have been administered as aerosols for many years, none are approved by the FDA for administration by inhalation. TOBI was approved by the FDA for the maintenance therapy of patients 6 years or older with cystic fibrosis (CF) who have between 25% and 75% of predicted forced expiratory volume in 1 second (FEV(1)), are colonized with Pseudomonas aeruginosa, and are able to comply with the prescribed medical regimen. TOBI was not approved for the therapy of acute pulmonary exacerbations in patients with CF nor was it approved for use in patients without CF. Currently, no other antibiotics are approved for administration by inhalation to patients with or without CF. The purpose of this statement is to briefly summarize the data that supported approval for licensure of TOBI and to provide recommendations for its safe use. The pharmacokinetics of inhaled aminoglycosides and problems associated with aerosolized antibiotic treatment, including environmental contamination, selection of resistant microbes, and airway exposure to excipients in intravenous formulations, will be discussed." @default.
• W1982258274 created "2016-06-24" @default.
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• W1982258274 date "2000-12-01" @default.
• W1982258274 modified "2023-10-13" @default.
• W1982258274 title "Technical Report: Precautions Regarding the Use of Aerosolized Antibiotics" @default.
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• W1982258274 doi "https://doi.org/10.1542/peds.106.6.e89" @default.
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